Antidiabetic Effects of Ethanolic Extract of Ficus glomerata (L.) Roots

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Author(s): Uday Deokate, Rohini R Pujari, Mohini C. Upadhye*.

Journal Name: Current Bioactive Compounds

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Background: Ficus glomerata Linn. Family Moraceace is a large deciduous tree distributed all over India from outer Himalayan ranges, Punjab, Khasia mountain, Chota Nagpur, Bihar, Orissa, West Bengal, Rajasthan, Deccan and common in South India. It is planted around the home and temples. It is found throughout the year, grows in evergreen forests, moist localities.

Objective: Antidiabetic activity of ethanolic extract of roots of Ficus glomerata (EEFG) belonging to the family Moraceace, was investigated in alloxan-induced diabetic rats.

Method: Thirty rats divided into 5 groups of 6 rats in each group. The alloxan was administered to the rats of all groups except normal control group through intraperitoneal route at a concentration of 140mg/kg body weight. EEFG was administered orally at a dose of 100mg/kg and 200 mg/kg body weight to alloxan-induced diabetic rats. The administration of the extract lasted for 11 days. Effect of the extract on glucose, cholesterol, triglycerides, high density lipoprotein and protein concentrations were analyzed.

Result: Treatment of the diabetic rats with the ethanolic extract showed significant (p<0.05) reduction in the levels of glucose, cholesterol, triglyceride. EEFG also showed significant improvement in glucose tolerance when subjected to oral glucose tolerance test.

Conclusion: Ficus glomerata root ethanolic extract showed that it possesses antidiabetic effect and may be used for the management of diabetes mellitus.

Keywords: Alloxan model, antidiabetic, diabetes, Ficus glomerata, herbal medicine, lipid profiles

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1573407215666190401151405
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