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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Research Article

Computational Protein-Protein Docking Reveals the Therapeutic Potential of Kunitz-type Venom against hKv1.2 Binding Sites

Author(s): Rida Khalid, Nighat Noureen, Mohammad Amjad Kamal and Sidra Batool*

Volume 18, Issue 5, 2019

Page: [382 - 404] Pages: 23

DOI: 10.2174/1871527318666190319140204

Price: $65

Abstract

Background & Objective: Kunitz-type venoms are bioactive proteins isolated from a wide variety of venomous animals. These venoms are involved in protease inhibitory activity or potassium channel blocking activity. Therefore, they are reported as an important source for lead drug candidates towards protease or channel associated diseases like neurological, metabolic and cardiovascular disorders.

Methods: This study aimed to check the inhibitory action of Kunitz-type venoms against potassium channels using computational tools.

Results: Among potassium channels, Human Voltage-Gated Potassium Channel 1.2 (hKv1.2) was used as a receptor whereas Kunitz-type peptides from the venoms of various species were selected as ligand dataset.

Conclusion: This study helped in finding the binding interface between the receptor and ligand dataset for their potential therapeutic use in treating potassium channelopathies.

Keywords: Kunitz-type venoms, human Kv1.2, docking, CS alpha/beta fold, autoimmune, metabolic.

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