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Clinical Cancer Drugs

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ISSN (Print): 2212-697X
ISSN (Online): 2212-6988

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Review Article

Targeting Breast Cancer Stem Cells (BCSCs) with Liposomal Formulations

Author(s): Sumayah Al-Mahmood*

Volume 6, Issue 1, 2019

Page: [3 - 7] Pages: 5

DOI: 10.2174/2212697X06666190318150757

Abstract

Breast cancer stem cells (BCSCs) are a small proportion of cells that may be responsible for improving the resistance of cancer cells to the treatment and metastasis of breast cancer (MBC). Nanovehicles such as liposomes are extensively explored for diagnosis, treatment, and imaging of cancer. Targeted therapy with nanoparticles can be used to overcome the chemoresistance problem of cancer stem cells. Liposomes are lipid bilayer nanocarriers that have the ability to inhibit Pglycoprotein to overcome multidrug resistance that makes liposome ideal choice for using in BCSCs therapy. The main objective of this review is to describe novel liposomal formulations that are used in targeting BCSCs, which help in improving breast cancer treatment.

Keywords: Breast cancer stem cells, liposomes, drug delivery, nanotechnology, breast cancer, targeted treatment.

Graphical Abstract

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