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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Exploring the Chemistry and Therapeutic Potential of Triazoles: A Comprehensive Literature Review

Author(s): Ankit Jain and Poonam Piplani*

Volume 19, Issue 16, 2019

Page: [1298 - 1368] Pages: 71

DOI: 10.2174/1389557519666190312162601

Price: $65

Abstract

Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role in the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. Structural modification of this scaffold could be helpful in the generation of new therapeutically useful agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole, there is still a lot of scope to achieve drug discovery break-through in this area. Upcoming therapeutic prospective of this moiety has captured the attention of medicinal chemists to synthesize novel triazole derivatives. The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological activities of the triazole nucleus in the present review. Information regarding the marketed triazole derivatives has also been incorporated. The objective of the review is to provide insights to designing and synthesizing novel triazole derivatives with advanced and unexplored pharmacological implications.

Keywords: 1, 2, 3-Triazole, 1, 2, 4-triazole, pharmacological activities, anti-tumor, antimicrobial, clinical indications.

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