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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

4H-1,3-Benzothiazin-4-one a Promising Class Against MDR/XDR-TB

Author(s): Marcus Vinicius Nora de Souza* and Thais Cristina Mendonça Nogueira

Volume 19, Issue 8, 2019

Page: [567 - 578] Pages: 12

DOI: 10.2174/1568026619666190305130809

Price: $65

Abstract

Nowadays, tuberculosis (TB) is an important global public health problem, being responsible for millions of TB-related deaths worldwide. Due to the increased number of cases and resistance of Mycobacterium tuberculosis to all drugs used for the treatment of this disease, we desperately need new drugs and strategies that could reduce treatment time with fewer side effects, reduced cost and highly active drugs against resistant strains and latent disease. Considering that, 4H-1,3-benzothiazin-4-one is a promising class of antimycobacterial agents in special against TB-resistant strains being the aim of this review the discussion of different aspects of this chemical class such as synthesis, mechanism of action, medicinal chemistry and combination with other drugs.

Keywords: Tuberculosis, Drugs, 4H-1, 3-benzothiazin-4-one, Synthesis, Mycobacterium tuberculosis, Multi drug resistant.

Graphical Abstract
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