Background: In this review, protein-protein interactions (PPI) were defined, and their behaviors
in normal in diseased conditions are discussed. Their status at nuclear, molecular and cellular level
was underscored, as for their interference in many diseases. Finally, the use of protein nanoscale structures
as possible carriers for drugs targeting PPIs was highlighted.
Objective: The objective of this review is to suggest a novel approach for targeting PPIs. By using protein
nanospheres and nanocapsules, a promising field of study can be emerged
Method: To solidify this argument, PPIs and their biological significance was discussed, same as there
role in hormone signaling. After that, we shed the light on the drugs that targets PPI and we suggested
the use of nanovectors to encapsulate these drugs to possibly achieve better results.
Conclusion: Protein based nanoparticles, due to their advantages, can be suitable carriers for drugs targeting
PPIs. This can open a new opportunity in the emerging field of multifunctional therapeutics.