Background: The modern immunology is targeted to the detailed study of various immunopathological
conditions at the molecular and cellular level, development of new methods for the prevention,
diagnostics and treatment of contagious and non-contagious diseases of humans and animals.
Methods: In the present work we took the rats with model of cyclophosphamide-induced immunodeficiency
and studied the features of gender impact of the complex extract of immunocompetent organs
(thymus, spleen and mesenteric lymph nodes) Sus scrofa and its separate fraction with molecular
weight less than 30 kDa administered to male and female rats.
Results: The impact of gender differences and tissue-specific biomolecules (30 kDa fraction) on hematological
parameters (leukocytes, erythrocytes, platelets), functional activity of immune system (IL-2,
IL-4, IL-6, complement system, IgG, IgM), biochemical parameters of hepatocytes functioning (activity
of ALP and LDG), carbohydrate metabolism (glucose) and lipid metabolism (triglycerides).
Conclusion: Decrease of ALP activity is caused by inhibition of bile formation in a liver after introduction
of cytostatic agent, and in contrast to complex extract, the administration of fraction 30 kDa
allows improving bile production in male rats.