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Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Review Article

Therapeutic Potential of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Author(s): Jing Jia, Baitao Ma, Shaoshuai Wang* and Ling Feng*

Volume 14, Issue 6, 2019

Page: [460 - 465] Pages: 6

DOI: 10.2174/1574888X14666190214162453

Price: $65

Abstract

Endothelial progenitor cells (EPCs) are implicated in multiple biologic processes such as vascular homeostasis, neovascularization and tissue regeneration, and tumor angiogenesis. A subtype of EPCs is referred to as endothelial colony-forming cells (ECFCs), which display robust clonal proliferative potential and can form durable and functional blood vessels in animal models. In this review, we provide a brief overview of EPCs’ characteristics, classification and origins, a summary of the progress in preclinical studies with regard to the therapeutic potential of human umbilical cord blood derived ECFCs (CB-ECFCs) for ischemia repair, tissue engineering and tumor, and highlight the necessity to select high proliferative CB-ECFCs and to optimize their recovery and expansion conditions.

Keywords: Endothelial colony forming cells (ECFCs), neovascularization, tissue engineering, tumor angiogenesis, vascular homeostasis, peripheral blood.

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