Abstract
Advances in genetic engineering and genomic studies facilitated the development of animal models of human diseases. To date, numerous models based on different animal species are available for the most socially significant human diseases, such as cardiovascular disorders, cancer, neurodegenerative and metabolic disorders. Modern genetic methods allow creating animals with certain genes up- or downregulated, as well as bearing specific mutations. However, this precision is not easy to translate into clinical practice: animal models still have their limitations, including both physiological and genetic differences between humans and animals and complexity of disease conditions that are difficult to reproduce. In this review, we will discuss the most relevant modern techniques that allow creating genetically engineered animal models.
Keywords: Gene editing, genetic engineering, animal model, CRISPR, human disease, Chromosome 1.
Current Molecular Medicine
Title:Human Disease Modelling Techniques: Current Progress
Volume: 18 Issue: 10
Author(s): Victor Yu. Glanz, Alexander N. Orekhov*Alexey V. Deykin
Affiliation:
- Institute of Gene Biology, Russian Academy of Sciences, Moscow,Russian Federation
Keywords: Gene editing, genetic engineering, animal model, CRISPR, human disease, Chromosome 1.
Abstract: Advances in genetic engineering and genomic studies facilitated the development of animal models of human diseases. To date, numerous models based on different animal species are available for the most socially significant human diseases, such as cardiovascular disorders, cancer, neurodegenerative and metabolic disorders. Modern genetic methods allow creating animals with certain genes up- or downregulated, as well as bearing specific mutations. However, this precision is not easy to translate into clinical practice: animal models still have their limitations, including both physiological and genetic differences between humans and animals and complexity of disease conditions that are difficult to reproduce. In this review, we will discuss the most relevant modern techniques that allow creating genetically engineered animal models.
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Cite this article as:
Glanz Yu. Victor , Orekhov N. Alexander *, Deykin V. Alexey , Human Disease Modelling Techniques: Current Progress, Current Molecular Medicine 2018; 18 (10) . https://dx.doi.org/10.2174/1566524019666190206204357
DOI https://dx.doi.org/10.2174/1566524019666190206204357 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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