Nephrotoxicity, a chronic renal disease that results from the accumulation of endogenous
and exogenous toxins in the kidney, disturbs the excretion and detoxification function of the kidney.
Metal-mediated nephrotoxicity is induced by toxic metals/metalloids such as mercury, lead, arsenic,
chromate, uranium, and cadmium. These materials become concentrated in the kidneys and injure the
nephrons. Developing strategies to detect these metal ions will enable the earlier identification of
kidney damage. An aptamer, an artificial antibody generated against a wide range of targets
including metal ions, may be the right tool for the detection of metal ions associated with renal injury.
The use of a detection system consisting of an aptamer and metallic nanoparticles is a potential
way to overcome nephrotoxicity. Here, we discuss the detection of metal-mediated nephrotoxicity
caused by metals/metalloids using the aptamer and nanomaterial-conjugated system.
Keywords: Nephrotoxicity, metal, metalloid, aptamer, nanomaterial, kidney.
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