Abstract
Autophagy is an intracellular biological catabolic process of mammalian cells to maintain the homeostasis. It plays a wide role in the clearance of damaged cellular organelles, misfolded or aggregated proteins like alpha-synuclein, β-amyloid peptides, Tau proteins and pathogens. Recent studies have clearly demonstrated that dysfunction in autophagy leads to the development of cancer, cardiomyopathy, chronic infection, neurodegenerative and other diseases. Therefore, modulation of autophagy has therapeutic value to cure the diseases including cancer using external stimuli. In this context, various researchers developed small molecules such as chloroquine, rapamycin, etc. for the treatment of cancer through autophagy. However, these molecules possess side effects which limit their use in the clinics. Therefore, nanomedicine approach could stand as an alternative treatment option to induce the autophagy in cancer therapy. Several investigators developed a variety of nanomaterials which themselves act as autophagy inducers or inhibitors. Considering this, the present review article will focus on the recent developments of nanomedicine in the area of autophagy that have been focused on the treatment of cancers. We also summarised the detailed mechanisms of nanoparticles mediated autophagy which could be helpful for developing new strategies to fight against cancer. Also, the present review article covers the current clinical status of nanomedicine and future challenges. Finally, we conclude with the future potential role of nanomedicine for autophagy induction in the cancer treatment.
Keywords: Cancer, Nanomedicine, Autophagy, Eukaryotic cell, Lysosome, Drug delivery.
Current Topics in Medicinal Chemistry
Title:Nanomedicine for Cancer Therapy Using Autophagy: An Overview
Volume: 18 Issue: 30
Author(s): Rajesh Kotcherlakota, Syed Tazib Rahaman and Chitta Ranjan Patra*
Affiliation:
- Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002,India
Keywords: Cancer, Nanomedicine, Autophagy, Eukaryotic cell, Lysosome, Drug delivery.
Abstract: Autophagy is an intracellular biological catabolic process of mammalian cells to maintain the homeostasis. It plays a wide role in the clearance of damaged cellular organelles, misfolded or aggregated proteins like alpha-synuclein, β-amyloid peptides, Tau proteins and pathogens. Recent studies have clearly demonstrated that dysfunction in autophagy leads to the development of cancer, cardiomyopathy, chronic infection, neurodegenerative and other diseases. Therefore, modulation of autophagy has therapeutic value to cure the diseases including cancer using external stimuli. In this context, various researchers developed small molecules such as chloroquine, rapamycin, etc. for the treatment of cancer through autophagy. However, these molecules possess side effects which limit their use in the clinics. Therefore, nanomedicine approach could stand as an alternative treatment option to induce the autophagy in cancer therapy. Several investigators developed a variety of nanomaterials which themselves act as autophagy inducers or inhibitors. Considering this, the present review article will focus on the recent developments of nanomedicine in the area of autophagy that have been focused on the treatment of cancers. We also summarised the detailed mechanisms of nanoparticles mediated autophagy which could be helpful for developing new strategies to fight against cancer. Also, the present review article covers the current clinical status of nanomedicine and future challenges. Finally, we conclude with the future potential role of nanomedicine for autophagy induction in the cancer treatment.
Export Options
About this article
Cite this article as:
Kotcherlakota Rajesh , Rahaman Tazib Syed and Patra Ranjan Chitta *, Nanomedicine for Cancer Therapy Using Autophagy: An Overview, Current Topics in Medicinal Chemistry 2018; 18 (30) . https://dx.doi.org/10.2174/1568026619666181224104838
DOI https://dx.doi.org/10.2174/1568026619666181224104838 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Is a "Mitochondrial Psychiatry" in the Future? A Review
Current Psychiatry Reviews Role of Antioxidants for the Treatment of Cardiovascular Diseases: Challenges and Opportunities
Current Pharmaceutical Design New and Under Explored Epigenetic Modulators in Search of New Paradigms
Medicinal Chemistry Indications of Anti-Inflammatory Drugs in Cardiac Diseases
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Engineered Nanoparticles Against MDR in Cancer: The State of the Art and its Prospective
Current Pharmaceutical Design Signal Transduction Inhibitors in the Treatment of Breast Cancer
Current Medicinal Chemistry - Anti-Cancer Agents Adeno-associated Viral Vectors for Correction of Inborn Errors of Metabolism: Progressing Towards Clinical Application
Current Pharmaceutical Design Clozapine Safety, 35 Years Later
Current Drug Safety The Failure of Immunomodulation Therapy in Heart Failure: Does the Statins “Paradigm” Prove the Rule?
Current Vascular Pharmacology Biochemical Markers of Cardiovascular Damage from Tobacco Smoke
Current Pharmaceutical Design Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?
Current Neuropharmacology Molecular Signature of Human amniotic Fluid Stem Cells During Fetal Development
Current Stem Cell Research & Therapy Mesenchymal Stromal Cell Therapy for Cardio Renal Disorders
Current Pharmaceutical Design Cell Therapy for Myocardial Regeneration
Current Molecular Medicine A Comprehensive Review on Ethnomedicinal, Pharmacological and Phytochemical Basis of Anticancer Medicinal Plants of Pakistan
Current Cancer Drug Targets Autophagy Inhibition Rescues Against Leptin-Induced Cardiac Contractile Dysfunction
Current Pharmaceutical Design Pathogenesis of Age-Related Cataract: A Systematic Review of Proteomic Studies
Current Proteomics The Role of Statins in the Activation of Heme Oxygenase-1 in Cardiovascular Diseases
Current Drug Targets Acetylation Control of Cancer Cell Metabolism
Current Pharmaceutical Design Drugs Targeting Parasite Lysosomes
Current Pharmaceutical Design