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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Resolving the Mystery of Ring Opening in the Synthesis of Benzo[d][1, 3]oxazin-4-one and Quinazolin-4(3H)-one

Author(s): Harun Patel*, Rahul Pawara and Sanjay Surana

Volume 16, Issue 11, 2019

Page: [898 - 905] Pages: 8

DOI: 10.2174/1570178616666181217114030

Price: $65

Abstract

Quinazoline is the six-membered heterocyclic ring system reported for its versatile biological activities. This characteristic feature of quinazoline makes it a good template for a lead generation library. Ring opening is one of the major concerns in the synthesis of quinazolin-4(3H)-one that results in diamide formation. Here, alternative fusion strategy is reported, which is a time-saving and costeffective method to overcome the ring opening problem associated with the synthesis of benzo[ d][1,3]oxazin-4-one and quinazolin-4(3H)-one.

Keywords: Quinazoline, ring opening, fusion, six-membered heterocyclic ring, fusion strategy, diamide formation.

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