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Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

General Research Article

Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

Author(s): Mohamed Eddouks*, Farid Khallouki, Robert W. Owen, Morad Hebi and Remy Burcelin

Volume 19, Issue 4, 2019

Page: [503 - 510] Pages: 8

DOI: 10.2174/1871530318666181113124727

Price: $65

Abstract

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A).

Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight.

Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001).

Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

Keywords: Arganimide A, streptozotocin, histopathological changes, lipid profile, diabetic rats, diabetes mellitus.

Graphical Abstract
[1]
Zimmet, P.; Alberti, K.G.; Magliano, D.J.; Bennett, P.H. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nat. Rev. Endocrinol., 2016, 12(10), 616-622.
[2]
Diagnosis and classification of diabetes mellitus. Diabetes Care, 2012, 35(Suppl. 1), S64-S71.
[3]
Tahrani, A.A.; Piya, M.K.; Kennedy, A.; Barnett, A.H. Glycaemic control in type 2 diabetes: targets and new therapies. Pharmacol. Ther., 2010, 125(2), 328-361.
[4]
Singh, A., Ed.; Herbalism, phytochemistry and ethnopharmacology; CRC Press, 2011.
[5]
Leiherer, A.; Mündlein, A.; Drexel, H. Phytochemicals and their impact on adipose tissue inflammation and diabetes. Vascul. Pharmacol., 2013, 58(1-2), 3-20.
[6]
Ghorbani, A. Phytotherapy for diabetic dyslipidemia: Evidence from clinical trials. Clin. Lipidol., 2013, 8, 311-319.
[7]
Charrouf, Z.; Guillaume, D. Ethnoeconomical, ethnomedical, and phytochemical study of Argania spinosa (L.) Skeels. J. Ethnopharmacol., 1999, 67(1), 7-14.
[8]
Guinda, A.; Rada, M.; Delgado, T.; Castellano, J.M. Pentacyclic triterpenic acids from Argania spinosa. Eur. J. Lipid Sci. Technol., 2011, 113(2), 231-237.
[9]
El Abbassi, A.; Khalid, N.; Zbakh, H.; Ahmad, A. Physicochemical characteristics, nutritional properties, and health benefits of argan oil: A review. Crit. Rev. Food Sci. Nutr., 2014, 54(11), 1401-1414.
[10]
Owen, R.W.; Mier, W.; Giacosa, A.; Hull, W.E.; Spiegelhalder, B.; Bartsch, H. Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene. Food Chem. Toxicol., 2000, 38(8), 647-659.
[11]
Khallouki, F.; Haubner, R.; Ricarte, I.; Erben, G.; Klika, K.; Ulrich, C.M.; Owen, R.W. Identification of polyphenolic compounds in the flesh of Argan (Morocco) fruits. Food Chem., 2015, 179, 191-198.
[12]
Farid, O.; Hebi, M.; Ajebli, M.; Hidani, A.E.; Eddouks, M. Antidiabetic effect of Ruta montana L. in streptozotocin-induced diabetic rats. J. Basic Clin. Physiol. Pharmacol., 2017, 28(3), 275-282.
[13]
Ajebli, M.; Eddouks, M. Buxus sempervirens L improves Streptozotocin-induced diabetes mellitus in rats. Cardiovasc. Hematol. Disord. Drug Targets, 2017, 17(2), 142-152.
[14]
Hebi, M.; Farid, O.; Ajebli, M.; Eddouks, M. Potent antihyperglycemic and hypoglycemic effect of Tamarix articulata Vahl. in normal and streptozotocin-induced diabetic rats. Biomed. Pharmacother., 2017, 87, 230-239.
[15]
Kolterman, O.G.; Gray, R.S.; Shapiro, G.; Scarlett, J.A.; Griffin, J.; Olefsky, J.M. The acute and chronic effects of sulfonylurea therapy in type II diabetic subjects. Diabetes, 1984, 33(4), 346-354.
[16]
Lebovitz, H.E.; Feinglos, M.N.; Bucholtz, H.K.; Lebovitz, F.L. Potentiation of insulin action: A probable mechanism for the anti-diabetic action of sulfonylurea drugs. J. Clin. Endocrinol. Metab., 1977, 45(3), 601-604.
[17]
Simonson, D.C.; Ferrannini, E.; Bevilacqua, S.; Smith, D.; Barrett, E.; Carlson, R.; DeFronzo, R.A. Mechanism of improvement in glucose metabolism after chronic glyburide therapy. Diabetes, 1984, 33(9), 838-845.
[18]
Lamela, M.; Cadavid, I.; Gato, A.; Calleja, J.M. Effects of Lythrum salicaria in normoglycemic rats. J. Ethnopharmacol., 1985, 14(1), 83-91.
[19]
Dias, T.R.; Alves, M.G.; Casal, S.; Oliveira, P.F.; Silva, B.M. Promising potential of dietary (poly) phenolic compounds in the prevention and treatment of diabetes mellitus. Curr. Med. Chem., 2017, 24(4), 334-354.
[20]
Wolff, S.P. Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br. Med. Bull., 1993, 49(3), 642-652.
[21]
Bolkent, S.; Bolkent, S.; Yanardag, R.; Tunali, S. Protective effect of vanadyl sulfate on the pancreas of streptozotocin-induced diabetic rats. Diabetes Res. Clin. Pract., 2005, 70(2), 103-109.
[22]
Yuan, M.; Konstantopoulos, N.; Lee, J.; Hansen, L.; Li, Z.W.; Karin, M.; Shoelson, S.E. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science, 2001, 293(5535), 1673-1677.
[23]
Kasetti, R.B.; Rajasekhar, M.D.; Kondeti, V.K.; Fatima, S.S.; Kumar, E.G.; Swapna, S.; Ramesh, B.; Rao, C.A. Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats. Food Chem. Toxicol., 2010, 48(4), 1078-1084.
[24]
Latha, R.C.R.; Daisy, P. Insulin-secretagogue, antihyperlipidemic and other protective effects of gallic acid isolated from Terminalia bellerica Roxb. in streptozotocin-induced diabetic rats. Chem. Biol. Interact., 2011, 189(1-2), 112-118.
[25]
Punithavathi, V.R.; Prince, P.S.M.; Kumar, R.; Selvakumari, J. Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats. Eur. J. Pharmacol., 2011, 650(1), 465-471.
[26]
Kusirisin, W.; Srichairatanakool, S.; Lerttrakarnnon, P.; Lailerd, N.; Suttajit, M.; Jaikang, C.; Chaiyasut, C. Antioxidative activity, polyphenolic content and anti-glycation effect of some Thai medicinal plants traditionally used in diabetic patients. Med. Chem., 2009, 5(2), 139-147.
[27]
Vetterli, L.; Brun, T.; Giovannoni, L.; Bosco, D.; Maechler, P. Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E β-cells and human islets through a SIRT1-dependent mechanism. J. Biol. Chem., 2011, 286(8), 6049-6060.
[28]
Khallouki, F.; Voggel, J.; Breuer, A.; Klika, K.D.; Ulrich, C.M.; Owen, R.W. Comparison of the major polyphenols in mature Argan fruits from two regions of Morocco. Food Chem., 2017, 221, 1034-1040.
[29]
Oki, J.C. Dyslipidemias in patients with diabetes mellitus: classification and risks and benefits of therapy. Pharmacotherapy, 1995, 15(3), 317-337.
[30]
Berrougui, H.; Ettaib, A.; Herrera Gonzalez, M.D.; Alvarez de Sotomayor, M.; Bennani-Kabchi, N.; Hmamouchi, M. Hypolipidemic and hypocholesterolemic effect of argan oil (Argania spinosa L.) in Meriones shawi rats. J. Ethnopharmacol., 2003, 89(1), 15-18.

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