Background and Objective: Warionia saharae Benth & Coss, a plant belonging to Asteraceae
family, is used for its anti-diabetic properties in Morocco. The objective of this study was to
evaluate the effect of tannins extracted from Warionia saharae (W. saharae) on blood glucose levels
and lipid profile in normal and streptozotocin(STZ)-induced diabetic rats.
Methods: Tannins (TE) were extracted from W. saharae using Soxhlet apparatus and different organic
solvents. Single and once daily repeated oral administration of TE (10 mg/kg) for 15 days were used to
evaluate the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test
tolerance, liver histopathological examination and in vitro antioxidant activity of TE were carried out
in this study.
Results: The results showed that TE was able to exert antihyperglycemic and lowering total cholesterol
effects as well as improvement of the high-density lipoprotein (HDL)-cholesterol serum level after 15
days of treatment. Furthermore, TE improved glucose tolerance, histopathological status of liver in
diabetic rats and demonstrated interesting antioxidant activity.
Conclusion: In conclusion, the present investigation revealed that TE possesses potent antidiabetic and
antihyperlipidemic activities as claimed in different ethnopharmacological practices.