Phage Display Technology and its Applications in Cancer Immunotherapy

Author(s): Yicun Wang , Shuohui Gao , Jiayin Lv , Yang Lin* , Li Zhou , Liying Han .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 19 , Issue 2 , 2019

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Graphical Abstract:


Abstract:

Background: Phage display is an effective technology for generation and selection targeting protein for a variety of purpose, which is based on a direct linkage between the displayed protein and the DNA sequence encoding it and utilized in selecting peptides, improving peptides affinity and indicating protein-protein interactions. Phage particles displaying peptide have the potential to apply in the identification of cell-specific targeting molecules, identification of cancer cell surface biomarkers, identification anti-cancer peptide, and the design of peptide-based anticancer therapy.

Method/Results: Literature searches, reviews and assessments about Phage were performed in this review from PubMed and Medline databases.

Conclusion: The phage display technology is an inexpensive method for expressing exogenous peptides, generating unique peptides that bind any given target and investigating protein-protein interactions. Due to the powerful ability to insert exogenous gene and display exogenous peptides on the surface, phages may represent a powerful peptide delivery system that can be utilized to develop rapid, efficient, safe and inexpensive cancer therapy methods.

Keywords: Phage, anti-cancer, cancer, immunotherapy, protein targeting, protein-protein interactions.

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VOLUME: 19
ISSUE: 2
Year: 2019
Page: [229 - 235]
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DOI: 10.2174/1871520618666181029140814
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