Abstract
Background: Large DNA poxviruses encode a diverse family of secreted proteins that modulate host inflammatory and antiviral responses, in particular by inhibiting one of the key players of the mammalian immune system, the tumor necrosis factor (TNF).
Methods: We investigated the effects of a recombinant variola (smallpox) virus TNF-decoy receptor (VARV-CrmB) in a murine model of contact dermatitis. Our results demonstrate that the VARV-CrmB protein significantly reduces the 2,4-dinitrochlorbenzene (DNCB)-induced migration of skin leukocytes during the sensitization phase and suppresses ear oedema during the elicitation phase of the contact reaction.
Results: Studies focusing on the bone marrow hematopoiesis in the contact dermatitis model revealed that the epicutaneous co-application of DNCB and VARV-CrmB protein normalized the DNCBinduced effects to control levels.
Conclusion: As an effective TNF antagonist, the VARV-CrmB protein might be conceived as a beneficial candidate for further research and development of therapeutic approaches in the field of the inflammatory skin diseases.
Keywords: Bone marrow, cell migration, contact dermatitis, hematopoiesis, human TNF (hTNF), murine TNF (muTNF), TNFdecoy receptor, variola virus.
Current Pharmaceutical Biotechnology
Title:Anti-inflammatory Effects of Variola Virus TNF Decoy Receptor in an Experimental Model of Contact Dermatitis
Volume: 19 Issue: 11
Author(s): Elena A. Viazovaia, Irina P. Gileva, Ludmila B. Toporkova, Sergei N. Shchelkunov and Irina A. Orlovskaya*
Affiliation:
- Federal State Budgetary Institution "Research Institute of Basic and Clinical Immunology", Novosibirsk,Russian Federation
Keywords: Bone marrow, cell migration, contact dermatitis, hematopoiesis, human TNF (hTNF), murine TNF (muTNF), TNFdecoy receptor, variola virus.
Abstract: Background: Large DNA poxviruses encode a diverse family of secreted proteins that modulate host inflammatory and antiviral responses, in particular by inhibiting one of the key players of the mammalian immune system, the tumor necrosis factor (TNF).
Methods: We investigated the effects of a recombinant variola (smallpox) virus TNF-decoy receptor (VARV-CrmB) in a murine model of contact dermatitis. Our results demonstrate that the VARV-CrmB protein significantly reduces the 2,4-dinitrochlorbenzene (DNCB)-induced migration of skin leukocytes during the sensitization phase and suppresses ear oedema during the elicitation phase of the contact reaction.
Results: Studies focusing on the bone marrow hematopoiesis in the contact dermatitis model revealed that the epicutaneous co-application of DNCB and VARV-CrmB protein normalized the DNCBinduced effects to control levels.
Conclusion: As an effective TNF antagonist, the VARV-CrmB protein might be conceived as a beneficial candidate for further research and development of therapeutic approaches in the field of the inflammatory skin diseases.
Export Options
About this article
Cite this article as:
Viazovaia A. Elena, Gileva P. Irina, Toporkova B. Ludmila, Shchelkunov N. Sergei and Orlovskaya A. Irina*, Anti-inflammatory Effects of Variola Virus TNF Decoy Receptor in an Experimental Model of Contact Dermatitis, Current Pharmaceutical Biotechnology 2018; 19 (11) . https://dx.doi.org/10.2174/1389201019666181029111011
DOI https://dx.doi.org/10.2174/1389201019666181029111011 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Changes in Gene Expression in the Rat Hippocampus Following Exposure to 56Fe Particles and Protection by Berry Diets
Central Nervous System Agents in Medicinal Chemistry Antioxidant Effects of Coumarins Include Direct Radical Scavenging, Metal Chelation and Inhibition of ROS-Producing Enzymes
Current Topics in Medicinal Chemistry Cystatin C, Adipokines and Cardiovascular Risk in HIV Infected Patients
Current HIV Research The Emerging Role of the Histamine H4 Receptor in Anti-inflammatory Therapy
Current Topics in Medicinal Chemistry Editorial [Hot Topic: Oxidative Balance: Experimental and Clinical Perspectives (Executive Editor: Fortunato Vesce)]
Current Pharmaceutical Design Editorial from Editor-in-Chief (The Role of Statins in the Intensive Care Unit)
Current Respiratory Medicine Reviews TRP Channels: New Potential Therapeutic Approaches in CNS Neuropathies
CNS & Neurological Disorders - Drug Targets Perinatal Brain Injury
Current Pediatric Reviews Recent Patents on Proteases and Kinases as Anti-Infective Agents: A Review
Recent Patents on Anti-Infective Drug Discovery Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting
Current Medicinal Chemistry Toll-Like Receptors and Kidney Diseases
Inflammation & Allergy - Drug Targets (Discontinued) An Unusual Presentation of a Rare Scleroderma Mimic: What is Behind the Scenes?
Current Rheumatology Reviews Current Highlights About the Safety of Inorganic Nanomaterials in Healthcare
Current Medicinal Chemistry Oncogenic MicroRNAs in the Genesis of Leukemia and Lymphoma
Current Pharmaceutical Design Editorial [Hot Topic: Non-Reproductive Effects of Sex Steroids: Their Immunoregulatory Role (Guest Editor: Jorge Morales-Monto)]
Current Topics in Medicinal Chemistry The Possible Role of Pathogenic and Non-Pathogenic Bacteria in Initiation and Exacerbation of Celiac Disease; A Comprehensive Review
Current Pharmaceutical Biotechnology Effect of Tetracyclines on IgE Allergic Responses and Asthma
Recent Patents on Inflammation & Allergy Drug Discovery Chondroitin Sulfate (CS) Lyases: Structure, Function and Application in Therapeutics
Current Protein & Peptide Science Can PPARγ Ligands Be Used in Cancer Therapy?
Current Medicinal Chemistry - Anti-Cancer Agents Bridge Between Neuroimmunity and Traumatic Brain Injury
Current Pharmaceutical Design