One New C21 Steroidal Glycosides from the Leaves of Cynanchum hancockianum

Title:One New C21 Steroidal Glycosides from the Leaves of Cynanchum hancockianum

Volume: 16 Issue: 7

Author(s): Shubei Yu, Xixi Lin, Yi Zheng, Zheng Wu, Wei Zheng and Liman Qiao*

Affiliation:

• Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou,China

Keywords: Cynanchum hancockianum, C21 steroids, glycoside, deoxysugars, nuclear magnetic resonance, cytotoxic activity.

Abstract: C21 steroids glycosides of various deoxysugars have been emerging from genus of Cynanchum. Besides classical C21 glycosides, many C21 glycosides with seco-ring aglycones attracted the extensive attention of many researchers. We conducted a systematic chemical investigation on Cynanchum hancockianum, which led to the isolation of one new seco-ring C21 steroidal glycosides. The new compound was identified as cynaascyriogenin 3-O-β-D-glucopyranosyl-(1-4)-α-L-cymaropyranosy-(1-4)- β-D-cymaropyranosyl-(1-4)-β-D-cymaropyranoside. The cytotoxic activities of the compound were evaluated using the A549 and MCF-7 cell lines, respectively. The IC50 values of the compound were 41.3 and 67.1µM, respectively. This is the first report on the isolation of seco-ring C21 steroidal glycosides from Cynanchum hancockianum.

Cite this article as:

Yu Shubei , Lin Xixi , Zheng Yi , Wu Zheng , Zheng Wei and Qiao Liman *, One New C21 Steroidal Glycosides from the Leaves of Cynanchum hancockianum, Letters in Organic Chemistry 2019; 16 (7) . https://dx.doi.org/10.2174/1570178615666181016113531