Generic placeholder image

Current Rheumatology Reviews

Editor-in-Chief

ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Review Article

Selenium and Autoimmune Diseases: A Review Article

Author(s): Maryam Sahebari, Zahra Rezaieyazdi and Mandana Khodashahi*

Volume 15, Issue 2, 2019

Page: [123 - 134] Pages: 12

DOI: 10.2174/1573397114666181016112342

Price: $65

Abstract

Background: Selenium is an essential trace element with fundamental effects on human biology. Trace elements deficiency is not an uncommon finding in autoimmune diseases. This deficiency may be a consequence of autoimmune diseases or may contribute to their etiology. With regard to evidence showing the association between selenium deficiency and generation of reactive oxygen species and subsequent inflammation, reviewing the role of selenium in collagen vascular diseases could help researchers to devise strategies for managing these diseases.

Objective: The present study aimed to evaluate the role of selenium and autoimmune rheumatic diseases.

Data Sources: PubMed, Scopus, Science Direct, and Google Scholar.

Study Eligibility Criteria: All the studies on the use of selenium without any limitations in terms of the preparation method, administration route, or formulation process were included in the study. The exclusion criteria were: 1) Articles published in languages other than English, 2) Administration of chemical and hormonal drugs rather than selenium, 3) Investigation of the effects of selenium on the autoimmune problems in animal models, and 4) Insufficiency of the presented data or poor description of the applied methods. Furthermore, review articles, meta-analyses, expert opinions, editorial letters, case reports, consensus statements, and qualitative studies were excluded from the study.

Data Extraction: In this systematic review, articles were evaluated through searching following keywords in combination with selenium: "autoimmune rheumatic diseases "or "scleroderma" or "systemic sclerosis" or "Behcet's disease" or "Sjögren syndrome" or "systemic lupus erythematosus" or "musculoskeletal diseases" or "rheumatoid arthritis" or "vasculitis" or "seronegative arthritis" or "antiphospholipid antibody syndrome".

Results: Of 312 articles, 280 were excluded and 32 articles were entered in this study. Based on the majority of studies assessing selenium level in patients with collagen vascular diseases, lower selenium levels were observed in these patients. Moreover, the majority of articles showed an improvement in clinical symptoms of collagen vascular diseases compared to controls after the treatment of patients with different dosages of L-selenomethionine.

Conclusion: A decrease in the serum level of selenium was noted in patients with autoimmune diseases, which may be a risk factor for inflammation and initiation of autoimmunity in these patients. A sufficient quantity of selenium has been shown to contribute to the management of complications of autoimmune diseases and even improved survival in patients with autoimmune diseases, which may be due to the anti-inflammatory effects of selenium. Since this issue is of clinical importance, it can be considered in potential nutrition interventions and have beneficial effects on some autoimmune diseases.

Keywords: Selenium, collagen vascular diseases, trace elements, rheumatoid arthritis, SLE, autoimmune diseases.

Graphical Abstract
[1]
Antico A, Tampoia M, Tozzoli R, Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev 2012; 12(2): 127-36.
[2]
Walsh SJ, Rau LM. Autoimmune diseases: A leading cause of death among young and middle-aged women in the United States. Am J Public Health 2000; 90(9): 1463-6.
[3]
Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 1997; 84(3): 223-43.
[4]
Al Faris NA, Ahmad D. Distribution of trace elements like calcium, copper, iron and zinc in serum samples of colon cancer - A case control study. JKSUS 2011; 23(4): 337-40.
[5]
Mertz W. The essential trace elements. Science 1981; 213(4514): 1332-8.
[6]
Colucci R, Dragoni F, Moretti S. Oxidative stress and immune system in vitiligo and thyroid diseases. Oxid Med Cell Longev 2015; 2015: 631927.
[7]
Kumagai S, Jikimoto T, Saegusa J. Pathological roles of oxidative stress in autoimmune diseases. Rinsho Byori 2003; 51(2): 126-32.
[8]
Rybicka I, Krawczyk M, Stanisz E, Gliszczyńska-Świgło A. Selenium in gluten-free products. Plant Foods Hum Nutr 2015; 70(2): 128-34.
[9]
Goldhaber SB. Trace element risk assessment: Essentiality vs. toxicity. Regul Toxicol Pharmacol 2003; 38(2): 232-42.
[10]
Sahebari M, Abrishami-Moghaddam M, Moezzi A, et al. Association between serum trace element concentrations and the disease activity of systemic lupus erythematosus. Lupus 2014; 23(8): 793-801.
[11]
Jeejeebhoy K. Zinc: An essential trace element for parenteral nutrition. Gastroenterology 2009; 137(5)(Suppl.): S7-S12.
[12]
Köhrle J. The trace element selenium and the thyroid gland. Biochimie 1999; 81(5): 527-33.
[13]
Tarp U, Overvad K, Thorling EB, Graudal H, Hansen JC. Selenium treatment in rheumatoid arthritis. Scand J Rheumatol 1985; 14(4): 364-8.
[14]
Erel A, Özsoy E, Biberoğlu G, et al. Serum levels of vitamins A, C, and E, β-carotene, selenium, and zinc in patients with Behçet’s disease: A controlled study. Biol Trace Elem Res 2003; 95(2): 97-106.
[15]
Tüzün A, Aydin A, Turan M. Erythrocyte antioxidant activity and trace element levels in Behçet’s disease. Biol Trace Elem Res 1998; 64(1-3): 169-74.
[16]
Okunuki Y, Usui Y, Takeuchi M, et al. Proteomic surveillance of autoimmunity in Behcet’s disease with uveitis: Selenium binding protein is a novel autoantigen in Behcet’s disease. Exp Eye Res 2007; 84(5): 823-31.
[17]
Santavuori P, Westermarck T, Rapola J, et al. Antioxidant treatment in Spielmeyer-Sjögren’s disease. Acta Neurol Scand 1985; 71(2): 136-45.
[18]
Herrick AL, Hollis S, Schofield D, et al. A double-blind placebo-controlled trial of antioxidant therapy in limited cutaneous systemic sclerosis. Clin Exp Rheumatol 2000; 18(3): 349-56.
[19]
Hill J, Bird HA. Failure of selenium-ace to improve osteoarthritis. Br J Rheumatol 1990; 29(3): 211-3.
[20]
Saglam K, Serce AF, Yilmaz MI, et al. Trace elements and antioxidant enzymes in Behçet’s disease. Rheumatol Int 2002; 22(3): 93-6.
[21]
Köse K, Doğan P, Aşçioğlu M, Erkiliç K, Aşçioğlu O. Oxidative stress and antioxidant defenses in plasma of patients with Behçet’s disease. Tohoku J Exp Med 1995; 176(4): 239-48.
[22]
Esalatmanesh K, Jamshidi A, Shahram F, et al. Study of the correlation of serum selenium level with Behcet’s disease. Int J Rheum Dis 2011; 14(4): 375-8.
[23]
Delilbaşi E, Turan B, Yücel E, Saşmaz R, Işimer A, Sayal A. Selenium and Behçet’s disease. Biol Trace Elem Res 1991; 28(1): 21-5.
[24]
Dogan P, Dogan M, Klockenkämper R. Determination of trace elements in blood serum of patients with Behçet disease by total reflection x-ray fluorescence analysis. Clin Chem 1993; 39(6): 1037-41.
[25]
Lourdudoss C, Elkan AC, Hafström I, et al. Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus. Lupus 2016; 25(14): 1602-9.
[26]
González S, Gutie Rrez-Díaz I, Ló Pez P, et al. Microbiota and oxidant-antioxidant balance in systemic lupus erythematosus. Nutr Hosp 2017; 34(4): 934-41.
[27]
Lundberg AC, Akesson A, Akesson B. Dietary intake and nutritional status in patients with systemic sclerosis. Ann Rheum Dis 1992; 51(10): 1143-8.
[28]
Hughes M, Cooper GJ, Wilkinson J, New P, Guy JM, Herrick AL. Abnormalities of selenium but not of copper homeostasis may drive tissue fibrosis in patients with systemic sclerosis. Rheumatology (Oxford) 2015; 54(4): 747-8.
[29]
Herrick AL, Worthington H, Rieley F, et al. Dietary intake of micronutrient antioxidants in relation to blood levels in patients with systemic sclerosis. J Rheumatol 1996; 23(4): 650-3.
[30]
Tikly M, Channa K, Theodorou P, Gulumian M. Lipid peroxidation and trace elements in systemic sclerosis. Clin Rheumatol 2006; 25(3): 320-4.
[31]
Yazar M, Sarban S, Kocyigit A, Isikan UE. Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis. Biol Trace Elem Res 2005; 106(2): 123-32.
[32]
Peretz A, Siderova V, Nève J. Selenium supplementation in rheumatoid arthritis investigated in a double blind, placebo-controlled trial. Scand J Rheumatol 2001; 30(4): 208-12.
[33]
Tarp U, Overvad K, Thorling EB, Graudal H, Hansen JC. Selenium treatment in rheumatoid arthritis. Scand J Rheumatol 1985; 14(4): 364-8.
[34]
Aaseth J, Haugen M, Førre O. Rheumatoid arthritis and metal compounds--perspectives on the role of oxygen radical detoxification. Analyst (Lond) 1998; 123(1): 3-6.
[35]
Tarp U, Stengaard-Pedersen K, Hansen JC, Thorling EB. Glutathione redox cycle enzymes and selenium in severe rheumatoid arthritis: Lack of antioxidative response to selenium supplementation in polymorphonuclear leucocytes. Ann Rheum Dis 1992; 51(9): 1044-9.
[36]
Tarp U, Hansen JC, Overvad K, Thorling EB, Tarp BD, Graudal H. Glutathione peroxidase activity in patients with rheumatoid arthritis and in normal subjects: Effects of long-term selenium supplementation. Arthritis Rheum 1987; 30(10): 1162-6.
[37]
Heinle K, Adam A, Gradl M, Wiseman M, Adam O. Selenium concentration in erythrocytes of patients with rheumatoid arthritis. Clinical and laboratory chemistry infection markers during administration of selenium. Med Klin (Munich) 1997; 92(Suppl. 3): 29-31. [Selenium concentration in erythrocytes of patients with rheumatoid arthritis. Clinical and laboratory chemistry infection markers during administration of selenium.].
[38]
Willers J, Fasse S, Putschky N, et al. Combined add-on supplementation of omega-3 fatty acids, vitamin E, vitamin A, copper, and selenium in rheumatoid arthritis. Food Nutr Sci 2011; 2(07): 714.
[39]
Möttönen T, Hannonen P, Seppälä O, Alfthan G, Oka M. Glutathione and selenium in rheumatoid arthritis. Clin Rheumatol 1984; 3(2): 195-200.
[40]
Köse K, Doğan P, Kardas Y, Saraymen R. Plasma selenium levels in rheumatoid arthritis. Biol Trace Elem Res 1996; 53(1-3): 51-6.
[41]
Aaseth J, Munthe E, Førre O, Steinnes E. Trace elements in serum and urine of patients with rheumatoid arthritis. Scand J Rheumatol 1978; 7(4): 237-40.
[42]
Honkanen VE. The factors affecting plasma glutathione peroxidase and selenium in rheumatoid arthritis: a multiple linear regression analysis. Scand J Rheumatol 1991; 20(6): 385-91.
[43]
Önal S, Nazıroğlu M, Çolak M, Bulut V, Flores-Arce MF. Effects of different medical treatments on serum copper, selenium and zinc levels in patients with rheumatoid arthritis. Biol Trace Elem Res 2011; 142(3): 447-55.
[44]
Li J, Liang Y, Mao H, Deng W, Zhang J. Effects of B-lymphocyte dysfunction on the serum copper, selenium and zinc levels of rheumatoid arthritis patients. Pak J Med Sci 2014; 30(5): 1064-7.
[45]
Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003; 423(6937): 356-61.
[46]
Vaghef-Mehrabany E, Homayouni-Rad A, Alipour B, Sharif SK, Vaghef-Mehrabany L, Alipour-Ajiry S. Effects of Probiotic Supplementation on Oxidative Stress Indices in Women with Rheumatoid Arthritis: A Randomized Double-Blind Clinical Trial. J Am Coll Nutr 2016; 35(4): 291-9.
[47]
Canter PH, Wider B, Ernst E. The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: A systematic review of randomized clinical trials. Rheumatology (Oxford) 2007; 46(8): 1223-33.
[48]
Sahebari M, Ayati R, Mirzaei H, et al. Serum trace element concentrations in rheumatoid arthritis. Biol Trace Elem Res 2016; 171(2): 237-45.
[49]
Witkowska AM, Kuryliszyn-Moskal A, Borawska MH, Hukałowicz K, Markiewicz R. A study on soluble intercellular adhesion molecule-1 and selenium in patients with rheumatoid arthritis complicated by vasculitis. Clin Rheumatol 2003; 22(6): 414-9.
[50]
Moustafa SR, Al-Taweel N, Mohsen F. Association of Boron, Copper, Germanium, Magnesium, Selenium and Zinc with Incidence of Rheumatoid Arthritis. Am J of Internal Medicine 2015; 3(3): 132-40.
[51]
Peretz A, Neve J, Duchateau J, Famaey JP. Adjuvant treatment of recent onset rheumatoid arthritis by selenium supplementation: preliminary observations. Br J Rheumatol 1992; 31(4): 281-2.
[52]
Knyazeva AK, Komarova EB, Kuvichko NN. Influence of selenium on clinical and laboratory parameters in patients with rheumatoid arthritis and subclinical hypothyroid dysfunction 2016.
[53]
Peretz A, Siderova V, Nève J. Selenium supplementation in rheumatoid arthritis investigated in a double blind, placebo-controlled trial. Scand J Rheumatol 2001; 30(4): 208-12.
[54]
Lourdudoss C, Elkan AC, Hafström I, et al. Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus. Lupus 2016; 25(14): 1602-9.
[55]
Almroth G, Westberg NG, Sandstrom BM. Normal zinc and selenium levels in patients with systemic lupus erythematosus. J Rheumatol 1985; 12(3): 633-4.
[56]
Carsons S, Bhimji S. Sjogren Syndrome 2017.
[57]
Mavragani CP, Moutsopoulos HM. Sjögren syndrome. CMAJ 2014; 186(15): E579-86.
[58]
Clausen J, Jensen GE, Nielsen SA. Selenium in chronic neurologic diseases. Multiple sclerosis and Batten’s disease. Biol Trace Elem Res 1988; 15: 179-203.
[59]
Khabbazi A, Rashtchizadeh N, Ghorbanihaghjo A, et al. The status of serum vitamin D in patients with active Behcet’s disease compared with controls. Int J Rheum Dis 2014; 17(4): 430-4.
[60]
Delilbaşi E, Turan B, Yücel E, Saşmaz R, Işimer A, Sayal A. Selenium and Behçet’s disease. Biol Trace Elem Res 1991; 28(1): 21-5.
[61]
Esalatmanesh K, Jamshidi A, Shahram F, et al. Study of the correlation of serum selenium level with Behcet’s disease. Int J Rheum Dis 2011; 14(4): 375-8.
[62]
Okunuki Y, Usui Y, Takeuchi M, et al. Proteomic surveillance of autoimmunity in Behcet’s disease with uveitis: selenium binding protein is a novel autoantigen in Behcet’s disease. Exp Eye Res 2007; 84(5): 823-31.
[63]
Adnan ZA. Diagnosis and treatment of scleroderma. Acta Med Indones 2008; 40(2): 109-12.
[64]
Herrick AL, Matucci Cerinic M. The emerging problem of oxidative stress and the role of antioxidants in systemic sclerosis. Clin Exp Rheumatol 2001; 19(1): 4-8.
[65]
Lundberg AC, Akesson A, Akesson B. Dietary intake and nutritional status in patients with systemic sclerosis. Ann Rheum Dis 1992; 51(10): 1143-8.
[66]
Juhlin L, Edqvist LE, Ekman LG, Ljunghall K, Olsson M. Blood glutathione-peroxidase levels in skin diseases: effect of selenium and vitamin E treatment. Acta Derm Venereol 1982; 62(3): 211-4.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy