Fluoxetine Inhibits Respiratory Growth of Candida glabrata and has Cytocidal Activity

(E-pub Ahead of Print)

Author(s): Ian Macreadie*.

Journal Name: Current Bioactive Compounds

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Abstract:

Background: Fluoxetine is a widely prescribed antidepressant that has associated antifungal activity. Methods: This study examined the growth inhibitory and cytotoxic effects of fluoxetine on Candida glabrata. Results: Fluoxetine inhibited growth of C. glabrata on media containing glucose as a carbon source: the inhibition was much greater when ethanol was the carbon source. In hypoosmotic conditions fluoxetine caused death of C. glabrata in one hour. Conclusion: Fluoxetine inhibits fermentative and mitochondrial function of C. glabrata. It rapidly kills C. glabrata in hypoosmotic conditions.

Keywords: Candida glabrata, Fluoxetine, Selective Serotonin Reuptake Inhibitor, Antifungal

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1573407214666181003150237
Price: $95