Background: Fluoxetine is a widely prescribed antidepressant that has associated antifungal
Methods: This study examined the growth inhibitory and cytotoxic effects of fluoxetine on Candida
Results: Fluoxetine inhibited growth of C. glabrata on media containing glucose as a carbon source: the
inhibition was much greater when ethanol was the carbon source. In hypoosmotic conditions fluoxetine
caused death of C. glabrata in one hour.
Conclusion: Fluoxetine inhibits fermentative and mitochondrial function of C. glabrata. It rapidly kills
C. glabrata in hypoosmotic conditions.
Keywords: Candida glabrata, Fluoxetine, Selective Serotonin Reuptake Inhibitor, Antifungal
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