Abstract
Background: Hybrids, composed of silver nanoparticles (AgNPs) dispersed inside a polymer matrix thus combining properties of both the components offer antibacterial activity and several advantages. Nevertheless, the development of antibacterial hybrid material comprising both novolac type phenolic resin and AgNPs remains one of the untouched issues in human healthcare.
Objective: We report herein the simple preparation of hybrid derived from functionalized novolac resin and AgNPs. The hybrid was tested for antibacterial activity towards Gram-positive and Gramnegative bacteria.
Method and Results: Preparation and characterization of functionalized novolac resin and hybrid were achieved. Gram-positive bacteria (Staphylococcus aureus MTCC 3160, Staphylococcus epidermidis NCIM2493, Bacillus subtilis) and Gram-negative bacteria (Pseudomonas aeruginosa ATCC27853, Escherichia coli) were used to test the bactericidal efficiency of hybrid. The antibacterial effectiveness of hybrid was determined in terms of the minimum inhibitory concentration (MIC). In addition, treatment with hybrid caused cytoplasmic contents leakage evidencing membrane damage.
Conclusion: The hybrid developed thus could provide opportunities to fabricate a wide range of antibacterial functional materials for different purposes in human health associated sectors.
Keywords: Antibacterial material, diethanolamine, functionalized novolac polymer, hybrid, minimum inhibitory concentration (MIC), silver nanoparticles.
Graphical Abstract
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The term "conjugated polymer" refers to "conjugated polymers", which is a sub-branch of polymer science. Conjugated polymers are polymers formed by adding various functional groups (usually organic compounds) to one end of a polymer chain. These functional groups can change the properties of the polymer or cause certain changes in ...read more
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