Abstract
Background & Objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways.
Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.
Keywords: Refractory epilepsy, ABC transporter, P-glycoprotein, breast cancer resistance protein, multidrug resistanceassociated protein, neuroinflammation, NF-κB, drug resistance.
CNS & Neurological Disorders - Drug Targets
Title:Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy
Volume: 17 Issue: 10
Author(s): Xiaolin Deng, Yangmei Xie and Yinghui Chen*
Affiliation:
- Department of Neurology, Huashan Hospital North, Fudan University, Shanghai,China
Keywords: Refractory epilepsy, ABC transporter, P-glycoprotein, breast cancer resistance protein, multidrug resistanceassociated protein, neuroinflammation, NF-κB, drug resistance.
Abstract: Background & Objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways.
Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.
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Cite this article as:
Deng Xiaolin , Xie Yangmei and Chen Yinghui*, Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy, CNS & Neurological Disorders - Drug Targets 2018; 17 (10) . https://dx.doi.org/10.2174/1871527317666180828121820
DOI https://dx.doi.org/10.2174/1871527317666180828121820 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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