Abstract
Background: It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice.
Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals.
Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice.
Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained.
Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory.
Keywords: Gamma-synuclein, working memory, passive-avoidance test, and amphetamine induced locomotion, soluble proteins, neural tissue.
CNS & Neurological Disorders - Drug Targets
Title:The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene
Volume: 17 Issue: 8
Author(s): Viktor S. Kokhan, Tat`yana G. Kokhan, Anna N. Samsonova, Vladimir P. Fisenko, Aleksey A. Ustyugov and Gjumrakch Aliev*
Affiliation:
- Institute of Physiologically Active Compounds RAS, Chernogolovka,Russian Federation
Keywords: Gamma-synuclein, working memory, passive-avoidance test, and amphetamine induced locomotion, soluble proteins, neural tissue.
Abstract: Background: It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice.
Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals.
Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice.
Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained.
Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory.
Export Options
About this article
Cite this article as:
Kokhan S. Viktor , Kokhan G. Tat`yana, Samsonova N. Anna , Fisenko P. Vladimir , Ustyugov A. Aleksey and Aliev Gjumrakch *, The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene, CNS & Neurological Disorders - Drug Targets 2018; 17 (8) . https://dx.doi.org/10.2174/1871527317666180726095734
DOI https://dx.doi.org/10.2174/1871527317666180726095734 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Metabolic Syndrome and Its Effect on the Brain: Possible Mechanism
CNS & Neurological Disorders - Drug Targets The PIK3CA Gene as a Mutated Target for Cancer Therapy
Current Cancer Drug Targets Hypoglycaemia and Cardiovascular Disease Risk in Patients with Diabetes
Current Pharmaceutical Design Microarray Technologies for Intracellular Kinome Analysis
Current Medicinal Chemistry Early Aged T-Cells in Immune-Mediated Diseases
Current Immunology Reviews (Discontinued) Patterns of Cognitive Decline and Rates of Conversion to Dementia in Patients with Degenerative and Vascular forms of MCI
Current Alzheimer Research The Quinoline Imidoselenocarbamate EI201 Blocks the AKT/mTOR Pathway and Targets Cancer Stem Cells Leading to a Strong Antitumor Activity
Current Medicinal Chemistry The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.
CNS & Neurological Disorders - Drug Targets In Vivo Transdermal Delivery of Leuprolide Using Microneedles and Iontophoresis
Current Pharmaceutical Biotechnology Fast Revelation of the Motif Mode for a Yeast Protein Interaction Network Through Intelligent Agent-Based Distributed Computing
Protein & Peptide Letters Phenomics of Vascular Disease: The Systematic Approach to the Combination Therapy
Current Vascular Pharmacology The Protective Effects of Jatrorrhizine on β-Amyloid (25-35)-Induced Neurotoxicity in Rat Cortical Neurons
CNS & Neurological Disorders - Drug Targets Predictability of Sustained Virological Response to Pegylated Interferon Alpha-2b Plus Ribavirin Therapy by Week-8 Viral Response in HIVPositive Patients with Chronic Hepatitis C Virus Infection
Current HIV Research Subject Index To Volume 4
Cardiovascular & Hematological Agents in Medicinal Chemistry History and Milestones of Mouse Models of Autoimmune Diseases
Current Pharmaceutical Design CRISPR/Cas9 Genome Editing: A Promising Tool for Therapeutic Applications of Induced Pluripotent Stem Cells
Current Stem Cell Research & Therapy Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer
Anti-Cancer Agents in Medicinal Chemistry Overcoming Barriers to Evidence-Based Diabetes Care
Current Diabetes Reviews Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-γ Ligand in Chronic Cerebral Hypoperfusion
Current Neurovascular Research Cannabinoids and Neuroprotection in Motor-Related Disorders
CNS & Neurological Disorders - Drug Targets