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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Review Article

A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies

Author(s): Valdemar Grill* and Bjørn O. Åsvold

Volume 15, Issue 3, 2019

Page: [172 - 173] Pages: 2

DOI: 10.2174/1573399814666180716152342

Price: $65

Abstract

Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical” type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.

Keywords: Autoantibodies, type 1 diabetes, type 2 diabetes, insulin secretion, glutamic acid decarboxylase, GADA.

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