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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

C-cinnamoyl Glycosides: An Emerging “Tail” for the Development of Selective Carbonic Anhydrase Inhibitors

Author(s): Helberth Llantén Martínez, Leonardo E. Riafrecha and Pedro A. Colinas*

Volume 26, Issue 15, 2019

Page: [2601 - 2608] Pages: 8

DOI: 10.2174/0929867325666180713122907

Price: $65

Abstract

Attachment of different tails to the well-known carbonic anhydrase (CA) pharmacophores has led to the development of several new CA inhibitors (CAIs). A very good example of such “tails” is constituted by carbohydrates, which represent a wide range of chemotypes, leading thus to a high number of new CAIs. In the last years, several C-cinnamoyl glycosides containing different scaffolds have been prepared and investigated as carbonic anhydrase inhibitors, showing that some of them are very potent and selective CAIs. This article will review the latest developments in the synthesis and biological activity of these Cglycosides.

Keywords: Carbohydrate, enzyme inhibition, antitumoral, tuberculosis, heterocycle, CAIs, carbonic anhydrase.

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