N-Substituted Aryl Sulphonamides as Potential Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation

Author(s): Neeraj Masand*, Satya P. Gupta, Ratan Lal Khosa.

Journal Name: Current Computer-Aided Drug Design

Volume 14 , Issue 4 , 2018

Graphical Abstract:


Abstract:

Introduction: A novel series of multifunctional anti-Alzheimer’s agents based on Nsubstituted aryl sulphonamides were designed and synthesized. During in vivo moderate to good anti- Alzheimer’s Disease (AD) activity was observed as correlated by the modulation of some selected biochemical markers of AD as well as during behavioral assessment.

Methods: Among the series, some compounds have shown multi-functional potency by inhibition of Acetylcholinesterase (AChE), Scopolamine induced oxidative stress and were found comparable to the standard drug. Successful modulation of biochemical markers of oxidative stress in AD, displays neuroprotective properties and did not exert any significant toxicity.

Results and Conclusion: Thus, the present study has evidently shown that these series of compounds have potential to be optimized as anti-AD agents with multi-functional properties. The aryl sulphonamide nucleus might serve as a promising lead candidate for developing novel anti-AD drug.

Keywords: Alzheimer`s disease, behavioral assessment, oxidative stress, Acetylcholinesterase (AChE), inhibition, histopathology.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 14
ISSUE: 4
Year: 2018
Page: [338 - 348]
Pages: 11
DOI: 10.2174/1573409914666180604115425
Price: $58

Article Metrics

PDF: 6