Introduction: A novel series of multifunctional anti-Alzheimer’s agents based on Nsubstituted
aryl sulphonamides were designed and synthesized. During in vivo moderate to good anti-
Alzheimer’s Disease (AD) activity was observed as correlated by the modulation of some selected biochemical
markers of AD as well as during behavioral assessment.
Methods: Among the series, some compounds have shown multi-functional potency by inhibition of
Acetylcholinesterase (AChE), Scopolamine induced oxidative stress and were found comparable to the
standard drug. Successful modulation of biochemical markers of oxidative stress in AD, displays neuroprotective
properties and did not exert any significant toxicity.
Results and Conclusion: Thus, the present study has evidently shown that these series of compounds
have potential to be optimized as anti-AD agents with multi-functional properties. The aryl sulphonamide
nucleus might serve as a promising lead candidate for developing novel anti-AD drug.