Abstract
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this disease. In this context, in this review we report the discovery of 3 classes of compounds that can simultaneously interact with more than one target of Mycobacterium tuberculosis.
Keywords: Anti tuberculosis drugs, Tuberculosis, Multi-target drugs, Targeting, Inhibition, Mycobacterium tuberculosis.
Current Topics in Medicinal Chemistry
Title:Multi-Target Antitubercular Drugs
Volume: 18 Issue: 9
Author(s): Jessika de Oliveira Viana, Hamilton Mitsugu Ishiki, Marcus Tullius Scotti and Luciana Scotti*
Affiliation:
- Cheminformatics Laboratory, Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraiba, Campus I, 58051-900, Joao Pessoa-PB,Brazil
Keywords: Anti tuberculosis drugs, Tuberculosis, Multi-target drugs, Targeting, Inhibition, Mycobacterium tuberculosis.
Abstract: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has high levels of mortality worldwide and has already gained resistance to first- and second-line drugs. The study by new chemical entities with promising activities becomes paramount to broaden the therapeutic strategies in the cure of the patients affected with this disease. In this context, in this review we report the discovery of 3 classes of compounds that can simultaneously interact with more than one target of Mycobacterium tuberculosis.
Export Options
About this article
Cite this article as:
de Oliveira Viana Jessika , Ishiki Mitsugu Hamilton , Scotti Tullius Marcus and Scotti Luciana *, Multi-Target Antitubercular Drugs, Current Topics in Medicinal Chemistry 2018; 18 (9) . https://dx.doi.org/10.2174/1568026618666180528124414
DOI https://dx.doi.org/10.2174/1568026618666180528124414 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Critical Parameters for Genome Editing Using Zinc Finger Nucleases
Mini-Reviews in Medicinal Chemistry Prolyl Oligopeptidase: A Rising Star on the Stage of Neuroinflammation Research
CNS & Neurological Disorders - Drug Targets Structure- and Ligand-Based Structure-Activity Relationships for a Series of Inhibitors of Aldolase
Current Computer-Aided Drug Design Rediscovery of Halogen Bonds in Protein-Ligand Complexes
Mini-Reviews in Medicinal Chemistry Benzothiazol Clubbed Imidazol-4-ones as Anti-fungal, Anti-tubercular and Anti-HIV-1 Agents: Their Synthesis and Molecular Docking Study
Letters in Drug Design & Discovery Studies on Chemistry, Spectroscopy and Antioxidant Activities of Chromium(III)-Hydrazide Complexes
Medicinal Chemistry Interleukin-6 In Rheumatoid Arthritis - From The Laboratory To The Bedside
Current Pharmaceutical Design Human Anthrax as a Re-Emerging Disease
Recent Patents on Anti-Infective Drug Discovery Graphical Abstracts:
Letters in Drug Design & Discovery Microwave-assisted Synthesis of 2-Styrylquinoline-4-carboxylic Acids as Antitubercular Agents
Medicinal Chemistry Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide
Current Organic Synthesis Lymphadenopathy as a Prodrome for Systemic Lupus Erythematous
Current Rheumatology Reviews PCR Designing and Amplification of Partial Hydrogenase Gene from Selected Hydrogen Producing Microorganisms
Current Biotechnology Emerging Trends in Endometriosis Treatment - Review
Current Women`s Health Reviews Review of Medicinal Plants Common to Traditional Chinese and Indian Medicines with Relevance to Non-Communicable Diseases
Current Traditional Medicine Kawasakis Disease, Acrodynia, and Mercury
Current Medicinal Chemistry Safety of Using Copper Oxide in Medical Devices and Consumer Products
Current Chemical Biology Submandibular Lymphadenitis in an Immunocompetent Female: Microbiological Confirmation is Need of the Hour
Infectious Disorders - Drug Targets Synthesis of Gold Mediated Biocompatible Nanocomposite of Lactone Enriched Fraction from Sahadevi (Vernonia cinerea Lees): An Assessment of Antimalarial Potential
Current Topics in Medicinal Chemistry Anomalous Vascular Supply of Bronchial Circulation in Cystic Fibrosis Patients with Massive Hemoptysis
Current Respiratory Medicine Reviews