Generic placeholder image

Current Women`s Health Reviews

Editor-in-Chief

ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

Research Article

HPV Prevalence and its Association with Perinatal Outcomes among Singleton Mothers: Analysis of Pregnancy Risk Assessment and Monitoring System (PRAMS) Data, 2004-2011

Author(s): Harpriya Kaur*, Delf Schmidt-Grimminger, Baojiang Chen, K.M. Monirul Islam, Steven W. Remmenga, Robin High and Shinobu Watanabe-Galloway

Volume 15, Issue 2, 2019

Page: [143 - 149] Pages: 7

DOI: 10.2174/1573404814666180517085022

Price: $65

Abstract

Background: Pregnancy may increase the risk of Human Papillomavirus (HPV) infection because of pregnancy induced immune suppression. The objective of this study was to use a large population-based dataset to estimate the prevalence of HPV infection and its association with adverse outcomes among pregnant women.

Methods: We analyzed Pregnancy Risk Monitoring System data from 2004-2011 (N=26,085) to estimate the self-reported HPV infection. Survey logistic procedures were used to examine the relationship between HPV infection and adverse perinatal outcomes.

Results: Approximately 1.4% of women were estimated to have HPV infection during their pregnancy. The prevalence of adverse outcomes in this sample was preterm birth (8.4%), preeclampsia (7.5%), low birth weight (6.3%) and premature rupture of membranes (2.8%). Compared to women without HPV infection, HPV infection positive women were much more likely to have had other infections such as chlamydia (9.23% vs. 2.12%, p-value <.0001), Group B Strep (21.7% vs. 10.04%, p-value <.0001), and herpes (7.17% vs. 1.07%, p-value <.0001). After adjusting for other risk factors including other infections, HPV infection was significantly associated with low birth weight (OR: 1.94, 95% CI: 1.14-3.30).

Conclusion: The study indicated a potential association between HPV infection and low birth weight. Because pregnant women with HPV infection are at higher risk of other infections, future research may focus on the roles of co-infection in the development of adverse perinatal effects.

Keywords: HPV, pregnancy, preterm birth, low birth weight, preeclampsia, PROM, perinatal, PRAMS.

Graphical Abstract
[1]
CDC. Genital HPV Infection-Fact Sheet2016 Available from: http://
www.cdc.gov/std/hpv/stdfact-hpv.htm Accessed Web Page, 2016.
[2]
Smith EM, Parker MA, Rubenstein LM, Haugen TH, Hamsikova E, Turek LP. Evidence for vertical transmission of HPV from mothers to infants. Infect Dis Obstet Gynecol 2010; 2010: 326369.
[3]
Hariri S, Unger ER, Sternberg M, et al. Prevalence of genital human papillomavirus among females in the United States, the National Health And Nutrition Examination Survey, 2003-2006. J Infect Dis 2011; 204(4): 566-73.
[4]
Cho G, Min KJ, Hong HR, et al. High-risk human papillomavirus infection is associated with premature rupture of membranes. BMC Pregnancy Childbirth 2013; 13: 173.
[5]
Weinberg ED. Pregnancy-associated depression of cell-mediated immunity. Rev Infect Dis 1984; 6(6): 814-31.
[6]
McDonnold M, Dunn H, Hester A, et al. High risk human papillomavirus at entry to prenatal care and risk of preeclampsia. Am J Obstet Gynecol 2014; 210(2): 138.e1-5.
[7]
Niyibizi J, Zanré N, Mayrand M-H, Trottier H. The association between adverse pregnancy outcomes and maternal human papillomavirus infection: A systematic review protocol. Syst Rev 2017; 6(1): 53.
[8]
CDC. PRAMS. 2015;. http://www.cdc.gov/prams/statesyearsdata.
htm Accessed Web Page, 2015.
[9]
ACOG Committee on Obstetric Practice. ACOG Committee on Practice Bulletins--Obstetrics. ACOG Practice bulletin no.33: Diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol 2002; 99(1): 159-67.
[10]
Qazi G. Obstetric and perinatal outcome of multiple pregnancy. J Coll Physicians Surg Pak 2011; 21(3): 142-5.
[11]
Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371(9606): 75-84.
[12]
Liu P, Xu L, Sun Y, Wang Z. The prevalence and risk of human papillomavirus infection in pregnant women. Epidemiol Infect 2014; 142(8): 1567-78.
[13]
Waller J, Marlow LA, Wardle J. The association between knowledge of HPV and feelings of stigma, shame and anxiety. Sex Transm Infect 2007; 83(2): 155-9.
[14]
Johnson HL, Ghanem KG, Zenilman JM, Erbelding EJ. Sexually transmitted infections and adverse pregnancy outcomes among women attending inner city public sexually transmitted diseases clinics. Sex Transm Dis 2011; 38(3): 167-71.
[15]
Waight MT, Rahman MM, Soto P, Tran T. Sexually transmitted diseases during pregnancy in Louisiana, 2007-2009: high-risk populations and adverse newborn outcomes. J La State Med Soc 2013; 165(4): 219-26.
[16]
Valero de Bernabé J, Soriano T, Albaladejo R, et al. Risk factors for low birth weight: a review. Eur J Obstet Gynecol Reprod Biol 2004; 116(1): 3-15.
[17]
Gomez LM, Ma Y, Ho C, McGrath CM, Nelson DB, Parry S. Placental infection with human papillomavirus is associated with spontaneous preterm delivery. Hum Reprod 2008; 23(3): 709-15.
[18]
Salafia CM, Pezzullo JC, Ghidini A, Lopez-Zeno JA, Whittington SS. Clinical correlations of patterns of placental pathology in preterm pre-eclampsia. Placenta 1998; 19(1): 67-72.
[19]
da Silva Cardeal LB, Brohem CA, Correa TC, et al. Higher expression and activity of metalloproteinases in human cervical carcinoma cell lines is associated with HPV presence. Biochem Cell Biol 2006; 84(5): 713-9.
[20]
Ota A, Yonemoto H, Someya A, Itoh S, Kinoshita K, Nagaoka I. Changes in matrix metalloproteinase 2 activities in amniochorions during premature rupture of membranes. J Soc Gynecol Investig 2006; 13(8): 592-7.
[21]
Kato Y, Yamashita T, Ishikawa M. Relationship between expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 and invasion ability of cervical cancer cells. Oncol Rep 2002; 9(3): 565-9.
[22]
Kaur H, Schmidt-Grimminger D, Remmenga SW, Chen B, Islam KMM. Does Human papillomavirus affect pregnancy outcomes? An analysis of hospital data 2012-2014. Int J Womens Health Wellness 2015; 1(006): 2.
[23]
Heumann CL, Quilter LA, Eastment MC, Heffron R, Hawes SE. Adverse birth outcomes and maternal Neisseria gonorrhoeae infection: A population-based cohort study in Washington State. Sex Transm Dis 2017; 44(5): 266-71.
[24]
Liu B, Roberts CL, Clarke M, Jorm L, Hunt J, Ward J. Chlamydia and gonorrhoea infections and the risk of adverse obstetric outcomes: A retrospective cohort study. Sex Transm Infect 2013; 89(8): 672-8.
[25]
Shew ML, Ermel AC, Weaver BA, et al. Association of Chlamydia trachomatis infection with redetection of human papillomavirus after apparent clearance. J Infect Dis 2013; 208(9): 1416-21.
[26]
Samoff E, Koumans EH, Markowitz LE, et al. Association of Chlamydia trachomatis with persistence of high-risk types of human papillomavirus in a cohort of female adolescents. Am J Epidemiol 2005; 162(7): 668-75.
[27]
Shulman HB, Gilbert BC, Msphbrenda CG, Lansky A. The Pregnancy Risk Assessment Monitoring System (PRAMS): Current methods and evaluation of 2001 response rates. Public Health Rep 2006; 121(1): 74-83.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy