2, 5-Disubstituted Phthalimides: Design, Synthesis and Anticonvulsant Activity in scPTZ and MES Models

Title:2, 5-Disubstituted Phthalimides: Design, Synthesis and Anticonvulsant Activity in scPTZ and MES Models

Volume: 14 Issue: 4

Author(s): Atefeh Saadabadi, Babak Kohen, Maryam Irandoust, Hamed Shafaroodi, Tara Mohammadpour, Mahdi Rezayat and Asghar Davood*

Affiliation:

• Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran,Iran

Keywords: Phthalimide, isoindole-1, 3(2H)-dione, anticovulsant, Na channel, docking, maximal electroshock.

Abstract: Introduction: In this study, fifteen new 2,5-disubstituted analgouges of phthalimide were designed and synthesized using the appropriate synthetic route to evaluate anticonvulsant activity against the Maximal Electroshock (MES) and subcutaneous Pentylenetetrazole (scPTZ) compare to phenytoin as a positive control. The structures of the synthesized compounds were confirmed by FTIR, H-NMR, C-NMR and MASS spectroscopy.

Methods: All the tested compounds were found to be effective in the PTZ model at dose of 60 mg/kg and most of the compounds showed protection against MES test indicative of their ability to inhibit the seizure spread at all dose ranges. Compound 3 illustrated the best efficacy among all compounds and showed more potency than phenytoin in clonic seizure and was potent as phenytoin in tonic seizure.

Results & Discussion: Using a model of the Na channel, these derivatives were docked in the active site. Docking studies displayed that all synthesized compounds have more negative binding energy compare to reference drug and inhibition-constant less than phenytoin that means they can block the receptor more efficiently and usually form hydrophobic interactions or hydrogen bond interaction frequently with the domains I, II, III and rarely with domain IV.

Cite this article as:

Saadabadi Atefeh , Kohen Babak , Irandoust Maryam , Shafaroodi Hamed , Mohammadpour Tara , Rezayat Mahdi and Davood Asghar *, 2, 5-Disubstituted Phthalimides: Design, Synthesis and Anticonvulsant Activity in scPTZ and MES Models, Current Computer-Aided Drug Design 2018; 14 (4) . https://dx.doi.org/10.2174/1573409914666180516115450