Increased Serum Total Bile Acids can be Associated with a Small Hematoma Volume and Decreased Clinical Severity During Acute Intracerebral Hemorrhage

Title:Increased Serum Total Bile Acids can be Associated with a Small Hematoma Volume and Decreased Clinical Severity During Acute Intracerebral Hemorrhage

Volume: 15 Issue: 2

Author(s): Kaili Wang, Yu Zhang, Chongke Zhong, Danni Zheng, Jiaping Xu, Yanlin Zhang, Jijun Shi, Goudong Xiao, Xia Zhang, Huihui Liu, Zhichao Huang, Chun-Feng Liu, Shoujiang You*Yongjun Cao*

Affiliation:

• Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004,China

• Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004,China

Keywords: Total bile acids, intracerebral hemorrhage, hematoma volume, prognosis, stroke, coronary artery disease.

Abstract: Background: The impact of Total Bile Acids (TBA) level on clinical outcomes after acute Intracerebral Hemorrhage (ICH) is still not understood.

Objective: We investigated whether admission TBA level is associated with hematoma volume, stroke clinical severity, and 3-month outcomes in acute ICH patients.

Methods: A total of 335 ICH patients were prospectively enrolled. Patients were divided into four groups, according to the quartiles of serum TBA level at the time of admission. Three-month outcomes were evaluated by interviews with patients or their family members.

Results: The median hematoma volumes for the quartiles of TBA level (Q1 to Q4) were 12.0, 12.3, 10.0, and 6.7 mL (P<0.001) and the median National Institutes of Health Stroke Scale (NIHSS) scores were 8, 8, 6, and 5 (P=0.002), respectively. In the adjusted models, patients in the highest quartile (Q4) had smaller hematoma volumes (P=0.039) and lower NIHSS scores (P=0.037) than patients in Q1. At three months follow-up, there were 136 patients with poor outcomes (defined as having modified Rankin Scale scores≥3) and 46 cases of all-cause deaths. TBA level was not significantly associated with poor outcome nor all-cause death after adjusting for age, sex, hematoma volume, and baseline NIHSS(all P-trend≥0.380).

Conclusions: Higher admission TBA was associated with smaller hematoma volume and decreased clinical severity, but not three month outcomes in patients with acute ICH.

Cite this article as:

Wang Kaili , Zhang Yu , Zhong Chongke , Zheng Danni , Xu Jiaping, Zhang Yanlin , Shi Jijun , Xiao Goudong, Zhang Xia , Liu Huihui, Huang Zhichao , Liu Chun-Feng, You Shoujiang *, Cao Yongjun *, Increased Serum Total Bile Acids can be Associated with a Small Hematoma Volume and Decreased Clinical Severity During Acute Intracerebral Hemorrhage, Current Neurovascular Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567202615666180516114211