Abstract
In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the design and synthesis of new molecules with potential application in several diseases was highlighted. Organic synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a wide range of structural modifications for structure-activity relationship studies and improving or modulating the biological activity of the promising compounds.
Keywords: Polyphenols, polyphenol metabolites, chemical synthesis, medicinal chemistry, drugs, anticancer.
Current Pharmaceutical Design
Title:Polyphenols, their Metabolites and Derivatives as Drug Leads
Volume: 24 Issue: 19
Author(s): A. Filipa Almeida, Claudia Nunes dos Santos and Maria Rita Ventura*
Affiliation:
- Instituto de Tecnologia Quimica e Biologica Antonio Xavier, NOVA - Universidade Nova de Lisboa, Avenida da Republica, 2781- 901 Oeiras,Portugal
Keywords: Polyphenols, polyphenol metabolites, chemical synthesis, medicinal chemistry, drugs, anticancer.
Abstract: In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the design and synthesis of new molecules with potential application in several diseases was highlighted. Organic synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a wide range of structural modifications for structure-activity relationship studies and improving or modulating the biological activity of the promising compounds.
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Cite this article as:
Almeida Filipa A. , dos Santos Nunes Claudia and Ventura Rita Maria *, Polyphenols, their Metabolites and Derivatives as Drug Leads, Current Pharmaceutical Design 2018; 24 (19) . https://dx.doi.org/10.2174/1381612824666180516103609
DOI https://dx.doi.org/10.2174/1381612824666180516103609 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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