Abstract
Gastrointestinal (GI) mucosal integrity is based on the balance of aggressive and protective mechanisms. Mucosal damage may occur when the injurious factors become dominant or the mucosal defensive processes are impaired. The main target of the therapy against GI mucosal injury is the reduction of aggressive factors, however, the therapeutic possibilities for stimulation of mucosal defensive processes are rather limited. This overview focuses on the gastric and intestinal mucosal protective mechanisms and discusses the main targets that increase protective processes and increase the mucosal resistance to injurious stimuli at pre-epithelial, epithelial and sub-epithelial levels.
Keywords: Mucosal defense, gastropathy, enteropathy, nonsteroidal anti-inflammatory drugs, Mucosal damage, stimli, mucosal, damage.
Current Pharmaceutical Design
Title:Similar and Distinct Mechanisms in the Protective Processes of Upper and Lower Gastrointestinal Tract
Volume: 24 Issue: 18
Author(s): K. Gyires*, Sz. B. Laszlo, B. Lazar and Z. S. Zadori
Affiliation:
- Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvarad ter 4., 1089 Budapest,Hungary
Keywords: Mucosal defense, gastropathy, enteropathy, nonsteroidal anti-inflammatory drugs, Mucosal damage, stimli, mucosal, damage.
Abstract: Gastrointestinal (GI) mucosal integrity is based on the balance of aggressive and protective mechanisms. Mucosal damage may occur when the injurious factors become dominant or the mucosal defensive processes are impaired. The main target of the therapy against GI mucosal injury is the reduction of aggressive factors, however, the therapeutic possibilities for stimulation of mucosal defensive processes are rather limited. This overview focuses on the gastric and intestinal mucosal protective mechanisms and discusses the main targets that increase protective processes and increase the mucosal resistance to injurious stimuli at pre-epithelial, epithelial and sub-epithelial levels.
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Cite this article as:
Gyires K. *, Laszlo B. Sz. , Lazar B. and Zadori Z. S. , Similar and Distinct Mechanisms in the Protective Processes of Upper and Lower Gastrointestinal Tract, Current Pharmaceutical Design 2018; 24 (18) . https://dx.doi.org/10.2174/1381612824666180516101531
DOI https://dx.doi.org/10.2174/1381612824666180516101531 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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