Progressive Supranuclear Palsy: Clinical, Pharmacological and Bioethical Implications

(E-pub Ahead of Print)

Author(s): Ignazio Vecchio, Cristina Tornali, Giulia Malaguarnera, Nicola Luigi Bragazzi, Michele Malaguarnera*.

Journal Name: Current Alzheimer Research


The progressive supranuclear palsy is a progressive neurodegenerative disease characterized by Parkinsonism, oculomotor abnormalities, early postural instability and cognitive impairment. Neurodegeneration in PSP is associated with tau protein, but the mechanisms by which tau abnormalities lead to cell dysfunction and death are not well understood. Neuro-behavioural problems related to the fear and loss of autonomy can determinate many bioethical implications. Careful planning involving patients’ families, academic and industry researchers is necessary to ensure improvement in the quality of life.

Keywords: Progressive supranuclear palsy, tonopathy, movement disorders, bioethics, clinical ethics, cognitive disease

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(E-pub Ahead of Print)
DOI: 10.2174/1567205015666180507111958
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