Abstract
Background: Progesterone is a sex steroid hormone. Since it has been discovered, it is widely used in the prevention of spontaneous preterm birth, hormone replacement therapy and other gynecological conditions.
Methods: We will review the progesterone preparations based on a comprehensive study of papers and patents from the traditional preparations up through the very recent literatures.
Results: This review mainly concentrates on oral, vaginal and micro delivery systems, involving different ways to prepare progesterone preparations.
Conclusion: Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can be greatly increased.
Keywords: Delivery system, injection, microspheres, oral, progesterone preparations, vaginal.
Graphical Abstract
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
Tissue Distribution and Metabolism of Micro- and Nanoparticles and Medical Implants
With the continuous advancement of modern science and engineering, numerous functional materials and active molecules have been developed and utilized in various industrial, medical, and food applications. Many of these can enter the body, either actively or passively, and have significant and intricate impacts on human health. For example, biomaterials ...read more
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