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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Research Article

Synthesis Under Microwave Irradiation and Molecular Docking of Some Novel Bioactive Thiadiazoles

Author(s): Sobhi M. Gomha*, Mastora M. Edress, Zeinab A. Muhammad*, Hatem M. Gaber, Mohamed M. Amin and Islam K. Matar

Volume 19, Issue 5, 2019

Page: [437 - 447] Pages: 11

DOI: 10.2174/1389557518666180329122317

Price: $65

Abstract

Background: A novel series of fused imidazole was prepared from the reaction of 2- bromoacetyl-3-phenyl-1,3,4-thiadiazole with various heterocyclic amines under microwave irradiation. The structures of all the novel products were elucidated based on the elemental analysis and spectral data.

Results: In addition, the biological activity of the newly synthesized compounds was evaluated and the results obtained indicate their potency as anti-inflammatory, analgesic and anti- ulcer agents.

Conclusion: The binding mechanism of the most active compounds was studied using MOE to analyze the molecular interactions.

Keywords: 1, 3, 4-thiadiazoles, fused imidazoles, heterocyclic amines, microwave irradiation, anti-inflammatory, analgesic and anti-ulcer agents.

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