Synthesis, In Silico and Antifungal Studies of Novel Thiophene Analogues Containing Pyrazole Ring

Title:Synthesis, In Silico and Antifungal Studies of Novel Thiophene Analogues Containing Pyrazole Ring

Volume: 15 Issue: 11

Author(s): Helmi M. Al-Maqtari, Joazaizulfazli Jamalis*, Subhash Chander, Hasnah M. Sirat , Shivalingegowda Naveen, Neratur K. Lokanath, Siti P.M. Bohari, Deepak P. Bhagwat and Murugesan Sankaranarayanan

Affiliation:

• Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor,Malaysia

Keywords: Pyrazole, thiophene, antifungal, drug likeness, chalcone, synthesis.

Abstract: Background: In the current study, a series of novel thiophene chalcones (3a-g) and pyrazole containing thiophene derivatives (6a-g) were designed as potential anti-fungal agents and evaluated in silico for drug-likeness behavior.

Methods: The titled compounds were synthesized using Claisen–Schmidt reaction of 3-methyl-2- thiophenecarboxaldehyde (1) with several acetophenone derivatives (2a-g) followed by cyclization reactions using hydrazine hydrate to form new compounds (6a-g) in good to excellent yield. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR and Mass spectral analysis. All the synthesized chalcones (3a-g) and pyrazole derivatives (6a-g) were screened for antifungal potency using Candida albicans (MTCC 3958) and Aspergillus niger (MTCC 9933) using fluconazole as standard drug.

Results & Conclusion: The assay results revealed interesting finding that, compound 6c showed significant activity against both the tested fungal strains.

Cite this article as:

Al-Maqtari M. Helmi, Jamalis Joazaizulfazli*, Chander Subhash, Sirat M. Hasnah, Naveen Shivalingegowda, Lokanath K. Neratur, Bohari P.M. Siti, Bhagwat P. Deepak and Sankaranarayanan Murugesan, Synthesis, In Silico and Antifungal Studies of Novel Thiophene Analogues Containing Pyrazole Ring, Letters in Drug Design & Discovery 2018; 15 (11) . https://dx.doi.org/10.2174/1570180815666180328144325