Abstract
Several studies have investigated the risk factors associated with asthma. Both genetic and environmental factors are considered to contribute to asthma susceptibility. Individual genetic association studies usually suffer from small sample size leading to biased results. Meta-analysis is a powerful tool that has the potential to resolve this limitation by increasing the statistical power of analyses. The current review summarizes the recent knowledge concerning genetic factors involved in asthma predisposition based on meta-analyses. Using the keywords: asthma, meta-analysis, polymorphism, we searched Pubmed, Medline, Embase and Google Scholar databases for the associated articles. Genetic polymorphisms in twenty-three genes are associated with asthma risk in meta-analyses. However, polymorphisms in nine genes showed none significant association. These findings are used to assess the genetic risk factors and to understand the molecular pathways related to asthma.
Keywords: Asthma, genetic polymorphism, single nucleotide polymorphism, cytokine, genetic association, metaanalysis.
Current Molecular Medicine
Title:Update on Asthma Genetics: Results From Meta-Analyses of Candidate Gene Association Studies
Volume: 17 Issue: 10
Author(s): K. Tizaoui*, K. Hamzaoui and A. Hamzaoui
Affiliation:
- Department of Basic Sciences, Medicine Faculty of Tunis, Tunis El Manar University, 15 Rue Djebel Lakdar, 1007 Tunis,Tunisia
Keywords: Asthma, genetic polymorphism, single nucleotide polymorphism, cytokine, genetic association, metaanalysis.
Abstract: Several studies have investigated the risk factors associated with asthma. Both genetic and environmental factors are considered to contribute to asthma susceptibility. Individual genetic association studies usually suffer from small sample size leading to biased results. Meta-analysis is a powerful tool that has the potential to resolve this limitation by increasing the statistical power of analyses. The current review summarizes the recent knowledge concerning genetic factors involved in asthma predisposition based on meta-analyses. Using the keywords: asthma, meta-analysis, polymorphism, we searched Pubmed, Medline, Embase and Google Scholar databases for the associated articles. Genetic polymorphisms in twenty-three genes are associated with asthma risk in meta-analyses. However, polymorphisms in nine genes showed none significant association. These findings are used to assess the genetic risk factors and to understand the molecular pathways related to asthma.
Export Options
About this article
Cite this article as:
Tizaoui K.*, Hamzaoui K. and Hamzaoui A. , Update on Asthma Genetics: Results From Meta-Analyses of Candidate Gene Association Studies, Current Molecular Medicine 2017; 17 (10) . https://dx.doi.org/10.2174/1566524018666180322162646
DOI https://dx.doi.org/10.2174/1566524018666180322162646 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Low Rank Representation and Its Application in Bioinformatics
Current Bioinformatics Patent Selections
Recent Patents on Inflammation & Allergy Drug Discovery Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents
Letters in Drug Design & Discovery Structure and Function in COPD
Current Respiratory Medicine Reviews Pathophysiology of IgG4-Related Disease
Current Immunology Reviews (Discontinued) Aspects of the Stability and Bioavailability of Carbohydrates and Carbohydrate Derivatives
Mini-Reviews in Medicinal Chemistry Clinical Implications of Recent Insights into the Structural Biology of Beta2 Adrenoceptors
Current Drug Targets Use of Antihistamines in Ocular Therapy
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Oral Beclomethasone: A Review of its Use in Inflammatory Bowel Disease
Mini-Reviews in Medicinal Chemistry Bioactivities of Iridoids
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Effects of Curcumin on Immune Responses
Current Bioactive Compounds Advances in Asthma and COPD Treatment: Combination Therapy with Inhaled Corticosteroids and Long-Acting β2-Agonists.
Current Pharmaceutical Design SAGE Application in Hematological Research
Current Pharmaceutical Biotechnology Measurement of Antioxidant Activity and Antioxidant Compounds under Versatile Extraction Conditions: I. The Immuno-Biochemical Antioxidant Properties of Sweet Cherry (Prunus avium) Extracts
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Exploring Current Role of Nanotechnology Used in Food Processing Industry to Control Food Additives and their Biochemical Mechanisms
Current Drug Targets Transient Left Ventricular Acute Failure after Cocaine Use
Current Drug Research Reviews Gene Vectors for Cytokine Expression In Vivo
Current Pharmaceutical Design Immunological Mechanisms of Specific Allergen Immunotherapy
Inflammation & Allergy - Drug Targets (Discontinued) Vitamin D and Cystic Fibrosis Lung Disease
Mini-Reviews in Medicinal Chemistry Respiratory Effects of β-Adrenergic Receptor Blockers
Current Medicinal Chemistry