Abstract
Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer, antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides, fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines have also been investigated by several research groups. In this review, most of the synthesized and reported nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation and structure-reactivity are discussed.
Keywords: Biological activities, brightening agents, chalcones, fluorescence, heterocycles, 2-pyrazolines.
Anti-Cancer Agents in Medicinal Chemistry
Title:2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview
Volume: 18 Issue: 10
Author(s): Pramod Singh*, Jitendra Singh, Geeta J. Pant*Mohan S.M. Rawat
Affiliation:
- Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand,India
- Department of Chemistry, H.N.B.Garhwal University, (A Central University), Srinagar Garhwal, 246174 Uttarakhand,India
Keywords: Biological activities, brightening agents, chalcones, fluorescence, heterocycles, 2-pyrazolines.
Abstract: Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer, antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides, fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines have also been investigated by several research groups. In this review, most of the synthesized and reported nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation and structure-reactivity are discussed.
Export Options
About this article
Cite this article as:
Singh Pramod *, Singh Jitendra , Pant J. Geeta *, Rawat S.M. Mohan , 2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (10) . https://dx.doi.org/10.2174/1871520618666180313153407
DOI https://dx.doi.org/10.2174/1871520618666180313153407 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Prostaglandin J2 Family and the Cardiovascular System
Current Vascular Pharmacology Heavy Metals and Epigenetic Alterations in Brain Tumors
Current Genomics Management of Ovarian Cancer in Elderly
Reviews on Recent Clinical Trials Molecular Targets of Omega-3 Fatty Acids for Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry The Role of Pemetrexed in Second-Line Chemotherapy for Advanced Non-Small Cell Lung Cancer
Current Drug Targets Drug-Mediated Targeted Disruption of Multiple Protein Activities Through Functional Inhibition of the Hsp90 Chaperone Complex
Current Medicinal Chemistry Synthesis and Cytotoxic Activities of Difluoro-Dimethoxy Chalcones
Anti-Cancer Agents in Medicinal Chemistry Dual Drug Conjugate Loaded Nanoparticles for the Treatment of Cancer
Current Drug Delivery A Medicinal Mushroom: Phellinus Linteus
Current Medicinal Chemistry Utilizing Cancer - Functional Gene Set - Compound Networks to Identify Putative Drugs for Breast Cancer
Combinatorial Chemistry & High Throughput Screening Dendritic Cells in Esophageal Adenocarcinoma: The Currently Available Information and Possibilities to use Dendritic Cells for Immunotherapeutic Approaches
Current Pharmaceutical Design Procyanidin B2 3,3″-di-O-gallate Inhibits Endothelial Cells Growth and Motility by Targeting VEGFR2 and Integrin Signaling Pathways
Current Cancer Drug Targets Role of CHRNA5-A3 Genetic Locus Variants and Developing Drug for Chronic Obstructive Pulmonary Disease
Current Medicinal Chemistry Global Expression Studies of Schizophrenic Brain: A Meta-Analysis Study Linking Neurological Immune System with Psychological Disorders
CNS & Neurological Disorders - Drug Targets No Effect of Metformin on Ovarian Cancer Survival: A Systematic Review and Meta-Analysis of Cohort Studies
Current Pharmaceutical Design Recent Developments in Anti-Cancer Drug Research
Current Medicinal Chemistry Novel RNAi Therapy - Intron-Derived MicroRNA Drugs
Drug Design Reviews - Online (Discontinued) Potential Novel Treatments for Bipolar Depression: Ketamine, Fatty Acids, Anti-inflammatory Agents, and Probiotics
CNS & Neurological Disorders - Drug Targets Computational Study of the Binding Modes of Diverse DPN Analogues on Estrogen Receptors (ER) and the Biological Evaluation of a New Potential Antiestrogenic Ligand
Anti-Cancer Agents in Medicinal Chemistry Overview of Cantharidin and its Analogues
Current Medicinal Chemistry