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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

The Delicate Equilibrium between Oxidants and Antioxidants in Brain Glioma

Author(s): María Jesús Ramírez-Expósito and José Manuel Martínez-Martos*

Volume 17, Issue 4, 2019

Page: [342 - 351] Pages: 10

DOI: 10.2174/1570159X16666180302120925

Price: $65

Abstract

Gliomas are the most frequent brain tumors in the adult population and unfortunately the adjuvant therapies are not effective. Brain tumorigenesis has been related both to the increased levels of free radicals as inductors of severe damages in healthy cells, but also with the reduced response of endogenous enzyme and non-enzymatic antioxidant defenses. In turn, both processes induce the change to malignant cells. In this review, we analyzed the role of the imbalance between free radicals production and antioxidant mechanism in the development and progression of gliomas but also the influence of redox status on the two major distinctive forms of programmed cell death related to cancer: apoptosis and autophagy. These data may be the reference to the development of new pharmacological options based on redox microenvironment for glioma treatment.

Keywords: Glioma, reactive oxygen species, antioxidant systems, autophagy, apoptosis.

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