Natural Snake Venom Inhibitors and their Pharmaceutical Uses: Challenges and Possibilities

Title:Natural Snake Venom Inhibitors and their Pharmaceutical Uses: Challenges and Possibilities

Volume: 24 Issue: 16

Author(s): Soledad Lorena Saavedra*, Lucia Avila, Silvana Laura Giudicessi, Fernando Albericio, Silvia Andrea Camperi, Osvaldo Cascone and Maria Camila Martinez-Ceron*

Affiliation:

• Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Catedra de Biotecnologia, Junin 956, 1113, Buenos Aires,Argentina

• Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Catedra de Biotecnologia, Junin 956, 1113, Buenos Aires,Argentina

Keywords: Antivenom, protein, plant extracts, peptides, inhibition, metalloproteinases, phospholipase A2.

Abstract: Nowadays, treatment with specific antivenins is considered the only cure for snakebites accidents. However, access to antivenom obstructs the successful implementation of the World Health Organization international guidelines. In the last few years, natural organic compounds, peptides, and proteins with the ability to inhibit snake toxins and obtained from different sources such as plant extracts and animal blood have been proposed as antivenoms. In this work, we will focus on the inhibitors of the main venom toxins, phospholipases A2 and metalloproteinases, and their application as novel antivenoms.

Cite this article as:

Saavedra Lorena Soledad*, Avila Lucia, Giudicessi Laura Silvana, Albericio Fernando, Camperi Andrea Silvia , Cascone Osvaldo and Martinez-Ceron Camila Maria *, Natural Snake Venom Inhibitors and their Pharmaceutical Uses: Challenges and Possibilities, Current Pharmaceutical Design 2018; 24 (16) . https://dx.doi.org/10.2174/1381612824666180223172854