Abstract
Background: Several SNPs were identified through GWAS for their association with type 2 diabetes which has implications to pancreatic β-cell physiology.
Objective: We aimed to study the role of risk alleles of TCF7L2, KCNJ11, CDKN2A, CDKAL1, IGF2BP2, SLC30A8 and KCNQ1 along with pharmacokinetic variants in response to sulfonylureas.
Method: We performed a prospective study on 209 newly diagnosed subjects; treatment naive T2D subjects were recruited. Individuals were started with glibenclamide monotherapy and followed-up for 12 weeks. Genotyping was done, using PCR-RFLP and TETRA-ARMS PCR and confirmed by DNA sequencing.
Results: In univariate regression analysis, KCNJ11 (rs5219) was only the predictor for glibenclamide treatment failure.
Conclusion: The present data suggests a possible role of KCNJ11 gene in altered response to glibenclamide.
Keywords: Sulfonylurea, Glibenclamide, Genome Wide Association Studies (GWAS), Type 2 Diabetes, T-ARMSPCR, KCNJ11 gene.
Current Molecular Medicine
Title:Genetic Variants Identified from GWAS for Predisposition to Type 2 Diabetes Predict Sulfonylurea Drug Response
Volume: 17 Issue: 8
Keywords: Sulfonylurea, Glibenclamide, Genome Wide Association Studies (GWAS), Type 2 Diabetes, T-ARMSPCR, KCNJ11 gene.
Abstract: Background: Several SNPs were identified through GWAS for their association with type 2 diabetes which has implications to pancreatic β-cell physiology.
Objective: We aimed to study the role of risk alleles of TCF7L2, KCNJ11, CDKN2A, CDKAL1, IGF2BP2, SLC30A8 and KCNQ1 along with pharmacokinetic variants in response to sulfonylureas.
Method: We performed a prospective study on 209 newly diagnosed subjects; treatment naive T2D subjects were recruited. Individuals were started with glibenclamide monotherapy and followed-up for 12 weeks. Genotyping was done, using PCR-RFLP and TETRA-ARMS PCR and confirmed by DNA sequencing.
Results: In univariate regression analysis, KCNJ11 (rs5219) was only the predictor for glibenclamide treatment failure.
Conclusion: The present data suggests a possible role of KCNJ11 gene in altered response to glibenclamide.
Export Options
About this article
Cite this article as:
Genetic Variants Identified from GWAS for Predisposition to Type 2 Diabetes Predict Sulfonylurea Drug Response, Current Molecular Medicine 2017; 17 (8) . https://dx.doi.org/10.2174/1566524018666180222122653
DOI https://dx.doi.org/10.2174/1566524018666180222122653 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Leptin in Non-Autoimmune Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) Ablation of TRPV1 Elevates Nocturnal Blood Pressure in Western Diet-fed Mice
Current Hypertension Reviews Medicinal Plants Used in Iranian Traditional Medicine (ITM) as Contraceptive Agents
Current Pharmaceutical Biotechnology Affective Temperaments and Mood Disorders: A Review of Current Knowledge
Current Psychiatry Reviews Diabetes without Manifest Cardiovascular Disease: A Novel Approach in Risk Stratification and Treatment Selection
Current Diabetes Reviews Non-diabetic Glucose levels and Cancer Mortality: A Literature Review
Current Diabetes Reviews Nasal <i>In-situ</i> Gel: An Approach to Enhance Therapeutic Benefits of the Drug
Drug Delivery Letters The Review of Nanomaterials Inducing the Differentiation of Stem Cells into Chondrocyte Phenotypes in Cartilage Tissue Engineering
Current Stem Cell Research & Therapy Targeting MCP-1 to Reduce Vascular Complications of Obesity
Recent Patents on Cardiovascular Drug Discovery Microbial and Enzymatic Process for Xylitol Production from D-glucose
Current Organic Chemistry Dietary Patterns in Alzheimers Disease and Cognitive Aging
Current Alzheimer Research Virtual Screening Strategy Combined Bayesian Classification Model, Molecular Docking for Acetyl-CoA Carboxylases Inhibitors
Current Computer-Aided Drug Design Differential Influences of Gastric Bypass and Sleeve Gastrectomy on Plasma Nesfatin-1 and Obestatin Levels in Patients with Type 2 Diabetes Mellitus
Current Pharmaceutical Design Editorial (Thematic Issue: Controlled Release and Drug Delivery in Diseases)
Protein & Peptide Letters Neurohypophyseal Dysfunction During Septic Shock
Endocrine, Metabolic & Immune Disorders - Drug Targets Peptides as Tight Junction Modulators
Current Pharmaceutical Design Biological Basis of Ageing, Age-related Diseases and Interventions
Current Pharmacogenomics and Personalized Medicine Aminergic Control and Modulation of Honeybee Behaviour
Current Neuropharmacology Pathophysiological Mechanisms Linking Type 2 Diabetes and Dementia: Review of Evidence from Clinical, Translational and Epidemiological Research
Current Diabetes Reviews A Hybrid Binary Cuckoo Search and Genetic Algorithm for Feature Selection in Type-2 Diabetes
Current Bioinformatics