Colchicine in Renal Diseases: Present and Future

Author(s): Smaragdi Marinaki, Chrysanthi Skalioti, J.N. Boletis*.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 6 , 2018

Abstract:

Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment.

Colchicine is indicated in the prevention and treatment of gouty arthritis and familial Mediterranean fever. In this review, we summarize current and potentially future pharmacologic activities of colchicine in various renal disease entities along with pharmacokinetic and pharmacodynamic properties. Additionally, we will refer to main interactions of colchicine with medications used in renal medicine, as well as dosing recommendations in patients with reduced glomerular filtration rate.

Keywords: Colchicine, chronic kidney disease, fibrosis, inflammation, lipophilic alkaloid, gouty arthritis.

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Article Details

VOLUME: 24
ISSUE: 6
Year: 2018
Page: [675 - 683]
Pages: 9
DOI: 10.2174/1381612824666180123101313
Price: $58

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