Abstract
Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment.
Colchicine is indicated in the prevention and treatment of gouty arthritis and familial Mediterranean fever. In this review, we summarize current and potentially future pharmacologic activities of colchicine in various renal disease entities along with pharmacokinetic and pharmacodynamic properties. Additionally, we will refer to main interactions of colchicine with medications used in renal medicine, as well as dosing recommendations in patients with reduced glomerular filtration rate.
Keywords: Colchicine, chronic kidney disease, fibrosis, inflammation, lipophilic alkaloid, gouty arthritis.
Current Pharmaceutical Design
Title:Colchicine in Renal Diseases: Present and Future
Volume: 24 Issue: 6
Author(s): Smaragdi Marinaki, Chrysanthi Skalioti and J.N. Boletis*
Affiliation:
- National and Kapodistrian University of Athens, Medical School, Nephrology Department and Renal Transplantation Unit, Laiko Hospital Athens, Athens,Greece
Keywords: Colchicine, chronic kidney disease, fibrosis, inflammation, lipophilic alkaloid, gouty arthritis.
Abstract: Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment.
Colchicine is indicated in the prevention and treatment of gouty arthritis and familial Mediterranean fever. In this review, we summarize current and potentially future pharmacologic activities of colchicine in various renal disease entities along with pharmacokinetic and pharmacodynamic properties. Additionally, we will refer to main interactions of colchicine with medications used in renal medicine, as well as dosing recommendations in patients with reduced glomerular filtration rate.
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Cite this article as:
Marinaki Smaragdi , Skalioti Chrysanthi and Boletis J.N.*, Colchicine in Renal Diseases: Present and Future, Current Pharmaceutical Design 2018; 24 (6) . https://dx.doi.org/10.2174/1381612824666180123101313
DOI https://dx.doi.org/10.2174/1381612824666180123101313 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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