Abstract
Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine (ser/thr) kinase that was originally identified as a regulator of glycogen metabolism and coupled with insulin signaling. Due to multifunctionality of this enzyme, it is found to play an important role in the onset and progression of various human diseases. Thiazole nucleus has received special attention by medicinal chemists because of its wide therapeutic potential. The objective of this review is to cover all the aspects of GSK-3β enzyme including its clinical implications, types of inhibitors with special reference to thiazole as GSK-3β inhibitor. Literature search was performed using Pubmed/Medline and Google Scholar to search for articles published in English language.
Keywords: Thiazole, GSK-3β, GSK-3β inhibitor, heterocycles, protein kinases, enzyme.
Current Drug Discovery Technologies
Title:An Overview of Discovery of Thiazole Containing Heterocycles as Potent GSK-3β Inhibitors
Volume: 15 Issue: 3
Author(s): Deepika Sharma*, Anjleena Malhotra and Ranju Bansal
Affiliation:
- Chandigarh College of Pharmacy, Landran, Mohali-140307, Punjab,India
Keywords: Thiazole, GSK-3β, GSK-3β inhibitor, heterocycles, protein kinases, enzyme.
Abstract: Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine (ser/thr) kinase that was originally identified as a regulator of glycogen metabolism and coupled with insulin signaling. Due to multifunctionality of this enzyme, it is found to play an important role in the onset and progression of various human diseases. Thiazole nucleus has received special attention by medicinal chemists because of its wide therapeutic potential. The objective of this review is to cover all the aspects of GSK-3β enzyme including its clinical implications, types of inhibitors with special reference to thiazole as GSK-3β inhibitor. Literature search was performed using Pubmed/Medline and Google Scholar to search for articles published in English language.
Export Options
About this article
Cite this article as:
Sharma Deepika*, Malhotra Anjleena and Bansal Ranju , An Overview of Discovery of Thiazole Containing Heterocycles as Potent GSK-3β Inhibitors, Current Drug Discovery Technologies 2018; 15 (3) . https://dx.doi.org/10.2174/1570163815666180104120857
DOI https://dx.doi.org/10.2174/1570163815666180104120857 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Review on Rheumatoid Arthritis Interventions and Current Developments
Current Drug Targets Applications of Random Walk Model on Biological Networks
Current Bioinformatics Berberine as a Promising Safe Anti-Cancer Agent- Is there a Role for Mitochondria?
Current Drug Targets Advancement of Traditional Chinese Medicine in Regulation of Intestinal Flora: Mechanism-based Role in Disease Management
Recent Patents on Anti-Cancer Drug Discovery Therapeutic Potential of Drug Delivery by Means of Lipid Nanoparticles: Reality or İllusion?
Current Pharmaceutical Design Adult Stem Cells and Skeletal Muscle Regeneration
Current Gene Therapy Biomaterials for Gene Delivery Atelocollagen-mediated Controlled Release of Molecular Medicines
Current Gene Therapy Development of Yeast Molecular Display Systems Focused on Therapeutic Proteins, Enzymes, and Foods: Functional Analysis of Proteins and its Application to Bioconversion
Recent Patents on Biotechnology Biodiversity and Chemodiversity: Future Perspectives in Bioprospecting
Current Drug Targets Polymeric Nanocarriers and Nanoreactors: A Survey of Possible Therapeutic Applications
Current Pharmaceutical Design Potential Role for Dendritic Cells in Endothelial Dysfunction, Diabetes and Cardiovascular Disease
Current Pharmaceutical Design Long-Term Treatment With Raltegravir is Associated with Lower Triglycerides and Platelets Count in the Older HIV+ Population: Results from the Ral-Age Study
Current HIV Research Progress in Nutritional and Health Profile of Milk and Dairy Products: A Novel Drug Target
Endocrine, Metabolic & Immune Disorders - Drug Targets Past and Present of Imaging Modalities Used for Prostate Cancer Diagnosis: Androgen Receptor Targeted Imaging of Prostate Cancer as a Future Modality for Early, Rapid and Efficient Diagnosis
Current Medical Imaging GEPT Extract Reduces Aβ Deposition by Regulating the Balance Between Production and Degradation of Aβ in APPV717I Transgenic Mice
Current Alzheimer Research Molecularly Imprinted Polymers: Novel Discovery for Drug Delivery
Current Drug Delivery The Gut Mucosa as a Site for Induction of Regulatory T-Cells
Current Pharmaceutical Design Metabolic Reprogramming of Human Cells in Response to Oxidative Stress: Implications in the Pathophysiology and Therapy of Mitochondrial Diseases
Current Pharmaceutical Design Selenium: A Cure for Autoimmune Thyroiditis
Endocrine, Metabolic & Immune Disorders - Drug Targets Biomedical Consequences of Alcohol Use Disorders in the HIV-Infected Host
Current HIV Research