CAN Mediated Mechanochemical Synthesis of Substituted Pyridine Derivatives

Title:CAN Mediated Mechanochemical Synthesis of Substituted Pyridine Derivatives

Volume: 15 Issue: 8

Author(s): Radhika Khanna, Aarti Dalal, Kulbir Kadyan, Ramesh Kumar, Parvin Kumar and Ramesh C. Kamboj*

Affiliation:

• Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana,India

Keywords: CAN, 1, 4-DHP, Hantzsch reaction, catalysis, heterocycles, drugs.

Abstract: A simple, green and cost-effective protocol has been devised for the synthesis of 4-substituted-2,6-dimethyl-3,5-pyridinecarboxylates from Hantzsch-type 1,4-dihydropyridines via rapid oxidation in excellent yields using 1.5 equivalent of ceric ammonium nitrate within 15 minutes in solvent-free conditions. The method was able to furnish the products in excellent yields. The products obtained were characterized by their NMR and melting points data.

Cite this article as:

Khanna Radhika, Dalal Aarti, Kadyan Kulbir, Kumar Ramesh, Kumar Parvin and Kamboj C. Ramesh*, CAN Mediated Mechanochemical Synthesis of Substituted Pyridine Derivatives, Letters in Organic Chemistry 2018; 15 (8) . https://dx.doi.org/10.2174/1570178615666180102153707