Synthesis of 3-(7-Methylbenzo[d]oxazol-4-yl) Butanoic Acid: A Precursor of (+)-seco-Pseudopteroxazole and (+)-Pseudopteroxazole

Title:Synthesis of 3-(7-Methylbenzo[d]oxazol-4-yl) Butanoic Acid: A Precursor of (+)-seco-Pseudopteroxazole and (+)-Pseudopteroxazole

Volume: 15 Issue: 12

Author(s): Aurelio Ortiz*, Pedro Ramírez, Jacqueline Jiménez, Angel Mendoza and Estibaliz Sansinenea

Affiliation:

• Facultad de Ciencias Quimicas, Benemerita Universidad Autonoma de Puebla, Puebla 72570,Mexico

Keywords: (+)-seco-pseudopteroxazole, (+)-pseudopteroxazole, antituberculotic, Mycobacterium tuberculosis, nitration reaction, olefination.

Abstract: A novel synthesis of 3-(7-methylbenzo[d]oxazol-4-yl) butanoic acid as a possible precursor of (+)-seco-pseudopteroxazole and (+)-pseudopteroxazole is presented. This synthesis was performed from m-cresol where a Fries rearrangement, a nitration reaction and an olefination reaction were the key reactions to achieve the synthesis of 3-(7-methylbenzo[d]oxazol-4-yl) butanoic acid.

Cite this article as:

Ortiz Aurelio *, Ramírez Pedro , Jiménez Jacqueline , Mendoza Angel and Sansinenea Estibaliz , Synthesis of 3-(7-Methylbenzo[d]oxazol-4-yl) Butanoic Acid: A Precursor of (+)-seco-Pseudopteroxazole and (+)-Pseudopteroxazole, Letters in Organic Chemistry 2018; 15 (12) . https://dx.doi.org/10.2174/1570178615666171227142301