ScFv Improvement Approaches

Peyman        Bemani; Mozafar        Mohammadi; Ali        Hakakian

Abstract

The most common recombinant antibody format is the single chain fragment variable (scFv) which it contains the complete antigen-binding domains of an intact antibody. ScFv fragments have found vast medical and non-medical applications. Several approaches have been employed to increase the affinity, avidity and structural stability related to these antibody fragments. Most approaches related to scFv improvement have been included in this review.

Keywords: scFv, avidity, affinity, scFv stability, recombinant antibody, antibody fragments.

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Protein & Peptide Letters

Title:ScFv Improvement Approaches

Volume: 25 Issue: 3

Author(s): Peyman Bemani, Mozafar Mohammadi*Ali Hakakian

Affiliation:

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran,Iran

Keywords: scFv, avidity, affinity, scFv stability, recombinant antibody, antibody fragments.

Abstract: The most common recombinant antibody format is the single chain fragment variable (scFv) which it contains the complete antigen-binding domains of an intact antibody. ScFv fragments have found vast medical and non-medical applications. Several approaches have been employed to increase the affinity, avidity and structural stability related to these antibody fragments. Most approaches related to scFv improvement have been included in this review.

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Cite this article as:

Bemani Peyman , Mohammadi Mozafar *, Hakakian Ali , ScFv Improvement Approaches, Protein & Peptide Letters 2018; 25 (3) . https://dx.doi.org/10.2174/0929866525666171129225436

DOI https://dx.doi.org/10.2174/0929866525666171129225436	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305