Abstract
Background: Alzheimer’s disease (AD) is a public health priority all over the world. The difficulty of fighting the disease consists mostly in the complexity of symptoms and causes, in the still poor knowledge of its mechanisms and in the existence of a latent, asymptomatic, preclinical stage. Although many drugs are continuously screened in clinical studies for the treatment of Alzheimer’s disease, the unexpected lack of patient response and sometimes the important adverse effects make it a potential field of application for personalized medicine.
Objective: This perspective review proposes nanotechnology as a valuable tool for the application of personalized medicine to AD.
Methods: The aim of personalized medicine is the development of more patient-precise treatments based mostly on the knowledge of individual genetics as well as of disease progress, and of pharmacokinetics and metabolic response to available drugs. The optimization of new and more sensitive detection techniques is an important tool for obtaining the pool of data needed for prediction and understanding of patient response.
Results: Research in bionanosensors is already providing examples with high sensitivity for core and new biomarkers for AD. In therapy the functionalization of nanoparticle surface can add specificity for biological recognition or for improving the bioavailability. This would allow the administration of lower doses with less adverse effects due to the local targeting.
Conclusion: Taking into account the promising characteristics of nanoparticles as excellent candidate tools for precision medicine development, the establishment of better standard methods for safety assessment and production scale up would be desirable for the nanomaterial fruitful employment.
Keywords: Nanoparticles, Alzheimer, precision medicine, nanotechnology, targeted medicine, biosensors, neurodegeneration.
Current Medicinal Chemistry
Title:Nanotechnology in Personalized Medicine: A Promising Tool for Alzheimer’s Disease Treatment
Volume: 25 Issue: 35
Author(s): Laura De Matteis, Rafael Martín-Rapún and Jesús M. de la Fuente*
Affiliation:
- Instituto de Ciencia de Materiales de Aragon (ICMA), CSIC-Universidad de Zaragoza, Zaragoza,Spain
Keywords: Nanoparticles, Alzheimer, precision medicine, nanotechnology, targeted medicine, biosensors, neurodegeneration.
Abstract: Background: Alzheimer’s disease (AD) is a public health priority all over the world. The difficulty of fighting the disease consists mostly in the complexity of symptoms and causes, in the still poor knowledge of its mechanisms and in the existence of a latent, asymptomatic, preclinical stage. Although many drugs are continuously screened in clinical studies for the treatment of Alzheimer’s disease, the unexpected lack of patient response and sometimes the important adverse effects make it a potential field of application for personalized medicine.
Objective: This perspective review proposes nanotechnology as a valuable tool for the application of personalized medicine to AD.
Methods: The aim of personalized medicine is the development of more patient-precise treatments based mostly on the knowledge of individual genetics as well as of disease progress, and of pharmacokinetics and metabolic response to available drugs. The optimization of new and more sensitive detection techniques is an important tool for obtaining the pool of data needed for prediction and understanding of patient response.
Results: Research in bionanosensors is already providing examples with high sensitivity for core and new biomarkers for AD. In therapy the functionalization of nanoparticle surface can add specificity for biological recognition or for improving the bioavailability. This would allow the administration of lower doses with less adverse effects due to the local targeting.
Conclusion: Taking into account the promising characteristics of nanoparticles as excellent candidate tools for precision medicine development, the establishment of better standard methods for safety assessment and production scale up would be desirable for the nanomaterial fruitful employment.
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Cite this article as:
De Matteis Laura , Martín-Rapún Rafael and de la Fuente M. Jesús*, Nanotechnology in Personalized Medicine: A Promising Tool for Alzheimer’s Disease Treatment, Current Medicinal Chemistry 2018; 25 (35) . https://dx.doi.org/10.2174/0929867324666171012112026
DOI https://dx.doi.org/10.2174/0929867324666171012112026 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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