Abstract
There has been a growing interest in the rational design of multi-targeted drugs with the aim of enhancing overall efficacy and/or improving safety. The development of multi-targeted drugs might yield new avenues in the treatment of cancers that involve multiple pathogenic factors. In this review, we focus on the multi-targeted metal-based anticancer agents, which include platinum, ruthenium, rhodium, gold, silver, copper, cobalt, zinc, and nickel complexes. Future directions for the development of multi-targeted metal-based anticancer agents are also proposed.
Keywords: Multi-target, metal complexes, cytotoxicity, anticancer agents, nickel complexes, pathogenic factors.
Current Topics in Medicinal Chemistry
Title:Multi-Target Metal-Based Anticancer Agents
Volume: 17 Issue: 28
Author(s): Zhen-Feng Chen*, Chris Orvig and Hong Liang*
Affiliation:
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004,China
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004,China
Keywords: Multi-target, metal complexes, cytotoxicity, anticancer agents, nickel complexes, pathogenic factors.
Abstract: There has been a growing interest in the rational design of multi-targeted drugs with the aim of enhancing overall efficacy and/or improving safety. The development of multi-targeted drugs might yield new avenues in the treatment of cancers that involve multiple pathogenic factors. In this review, we focus on the multi-targeted metal-based anticancer agents, which include platinum, ruthenium, rhodium, gold, silver, copper, cobalt, zinc, and nickel complexes. Future directions for the development of multi-targeted metal-based anticancer agents are also proposed.
Export Options
About this article
Cite this article as:
Chen Zhen-Feng *, Orvig Chris and Liang Hong *, Multi-Target Metal-Based Anticancer Agents, Current Topics in Medicinal Chemistry 2017; 17 (28) . https://dx.doi.org/10.2174/1568026617666171004155437
DOI https://dx.doi.org/10.2174/1568026617666171004155437 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells
Current Topics in Medicinal Chemistry Diabetes Mellitus Type 1 During COVID-19: Psychological Symptoms and Eating Attitudes
Current Diabetes Reviews Neutralization of SARS-CoV-2 Spike Protein via Natural Compounds: A Multilayered High Throughput Virtual Screening Approach
Current Pharmaceutical Design Depression Discovery in Covid-19 Communities Using Deep Learning
Recent Patents on Engineering GAAP: A GUI-based Genome Assembly and Annotation Package
Current Genomics Synthesis, Molecular Docking, c-Met Inhibitions of 2,2,2-Trichloroethylidene- cyclohexane-1, 3-dione Derivatives Together with their Application as Target SARS-CoV-2 main Protease (Mpro) and as Potential anti-COVID-19
Combinatorial Chemistry & High Throughput Screening Dubious Results of Remdisivir Ultimately in Solidarity; Diversity of Severity of Illness is Doubtful
New Emirates Medical Journal A Systematic Review and Meta-Analysis of the Safety of Hydroxychloroquine in a Randomized Controlled Trial and Observational Studies
Current Reviews in Clinical and Experimental Pharmacology <i>In silico</i> Identification of Novel SARS-CoV-2 Main Protease and Nonstructural Protein 13 (nsp13) Inhibitors through Consensus Docking and Free Binding Energy Calculations
Combinatorial Chemistry & High Throughput Screening Quantitative Structure Activity Relationship (QSAR) Analysis of Substituted 4-Oxothiazolidines and 5-Arylidines as Lipoxygenase Inhibitors
Mini-Reviews in Medicinal Chemistry Pharmacotherapy in Neonatal and Pediatric Extracorporeal Membrane Oxygenation (ECMO)
Current Drug Metabolism The Feasibility of Low-dose Chest CT Acquisition Protocol for the Imaging of COVID-19 Pneumonia
Current Medical Imaging Epidemiology and Pathophysiology of Chronic Cough
Current Respiratory Medicine Reviews Positive Aspects, Negative Aspects and Challenges Associated with Stem Cell Therapy for COVID - 19: A Mini-review
Current Stem Cell Research & Therapy Computational Fluid Dynamics: Insights and Applications in the Pharmaceutical Field
Letters in Drug Design & Discovery Recent Advances on the Green Synthesis and Antioxidant Activities of Pyrazoles
Mini-Reviews in Medicinal Chemistry Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review
Anti-Cancer Agents in Medicinal Chemistry Remdesivir (GS-5734) in COVID-19 Therapy: The Fourth Chance
Current Drug Targets Probing the Neuro-psychological Changes Observed with the Administration of COVID-19 Drugs
Current Topics in Medicinal Chemistry Computational Studies and Biological Evaluation on Synthesized Lead 1,3- diphenyl-4,5-dihydro-1H-pyrazole Moiety as Anti-Infective Agents
Anti-Infective Agents