Abstract
Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for combinatorial as well as medicinal chemistry. This review presents a detailed overview on the synthesis, QSAR and pharmacological applications of pyrazole. In addition, it covers most recent reports on structural modifications on pyrazole illustrating vital structural activity relationship.
Keywords: Combinatorial chemistry, medicinal chemistry, pharmacological activity, pharmacophore, pyrazole, QSAR.
Mini-Reviews in Medicinal Chemistry
Title:The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review
Volume: 18 Issue: 11
Author(s): Jaya Dwivedi*, Swapnil Sharma, Sonika Jain and Aarti Singh
Affiliation:
- Department of Chemistry, Banasthali University, Banasthali Bansthali-304022,India
Keywords: Combinatorial chemistry, medicinal chemistry, pharmacological activity, pharmacophore, pyrazole, QSAR.
Abstract: Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for combinatorial as well as medicinal chemistry. This review presents a detailed overview on the synthesis, QSAR and pharmacological applications of pyrazole. In addition, it covers most recent reports on structural modifications on pyrazole illustrating vital structural activity relationship.
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Cite this article as:
Dwivedi Jaya *, Sharma Swapnil , Jain Sonika and Singh Aarti , The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review, Mini-Reviews in Medicinal Chemistry 2018; 18 (11) . https://dx.doi.org/10.2174/1389557517666170927160919
DOI https://dx.doi.org/10.2174/1389557517666170927160919 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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