Generic placeholder image

Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Effects of Apelin Peptides on Diabetic Complications

Author(s): Hong Chen, Chengyu Liu, Cheng Cheng, Ling Zheng and Kun Huang*

Volume 19, Issue 2, 2018

Page: [179 - 189] Pages: 11

DOI: 10.2174/1389203718666170918154728

Price: $65

Abstract

Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic complications. Here we summarize the current knowledge on the role of apelin in the pathogenesis of different diabetic complications. We also propose that similar to insulin resistance or leptin resistance, diabetics may also show apelin resistance. Potential clinical application of apelin and its analogue peptides in treating diabetic complications is discussed.

Keywords: Apelin, adipokine, diabetes, diabetic complications, metabolic disorder, cardiomyopathy.

Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy